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FLASH GENE
Symbol GNA12 contributors: npt/mct - updated : 19-09-2016
HGNC name guanine nucleotide binding protein (G protein) alpha 12
HGNC id 4380
Location 7p22.3      Physical location : 2.767.742 - 2.883.959
Synonym name
  • G alpha-12
  • guanine nucleotide-binding protein alpha-12 subunit
    • Synonym symbol(s) GB12, EVI73, gep, MGC104623, MGC99644, NNX3, RMP
    DNA
    TYPE functioning gene
    STRUCTURE 142.55 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4398 44.3 381 - 2008 18367648
    3 - 4347 - 364 - 2008 18367648
    5 - 4374 - 322 - 2008 18367648
    3 - 4246 - 305 - 2008 18367648
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivefemale systemplacenta  highly
    Visualeyeretina  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal mitochondrial targeting sequence
  • PKD1 interaction sites are likely to reside on exposed regions within the G protein helical domain
    • secondary structure three units (alpha, beta, gamma)
    conjugated LipoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans F18G5.3
    homolog to murine Gna12
    Homologene
    FAMILY
  • G-alpha family
    • CATEGORY protooncogene , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • modulator or transducer in various transmembrane signaling systems
  • heterotrimeric G protein alpha subunit specifically targeted to mitochondria and involved in the control of mitochondrial morphology and dynamics
  • important regulator of prostate cancer invasion
  • has a major role in regulating epithelial cell apoptosis through PP2A and JNK activation leading to loss of BCL2 protein expression
  • involved inbstress fiber formation and neurite retraction
  • regulated expression of HTR7 and GNA12-protein may represent a molecular mechanism by which serotonin
  • modulates IgG production, thus induces IgG antibody-mediated immune responses
  • may be a critical signaling molecule in TCR-induced IL2 production and also relay a signal to suppress Th2 and Th17 cell differentiation
  • specifically modulates formation of initial neuronal networks during early postnatal development
  • GNA12 and GNA14 play a key role in the genetic architecture underlying normal gray matter density (GMD) variation in frontal and parietal regions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DRD3 interaction with GNA12/GNA13 that increases sodium excretion may have a role in the regulation of blood pressure
  • MAPK8 activation is required for GNA12-induced invasion of breast cancer cells and MAPK8 is downstream of ROCK1 on this pathway
  • GNA12 plays a prominent role in endothelial cells (ECs) VWF secretion required for hemostasis and thrombosis
  • interaction of polycystin-1 (PKD1) and GNA12 is important for development of kidney cysts in autosomal dominant polycystic kidney disease (ADPKD)
  • CDH1/CTNNB1 signaling pathway is regulated by PKD1 and GNA12 via ADAM10
  • GPR56 regulates oligodendrocyte development via interactions with GNA12/GNA13 and RHOA
  • RGS22 had specific interactions with the heterotrimeric G protein GNA12 and GNA13 in the cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    constitutional     --over  
    higher in preeclampsia patients than in controls, by decreased methylation level
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may be targeted to limit invasion- and metastasis-induced prostate cancer patient mortality
    ANIMAL & CELL MODELS