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FLASH GENE
Symbol GNA11 contributors: mct - updated : 21-02-2015
HGNC name guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HGNC id 4379
Location 19p13.3      Physical location : 3.094.407 - 3.121.452
DNA
TYPE functioning gene
STRUCTURE 27.01 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status provisional
Physical map
LOC360200  polyserase 1 TIMM13 19p13.3 translocase of inner mitochondrial membrane 13 homolog (yeast) LMNB2 19p13.3 lamin B2 GADD45B 19p13.3 growth arrest and DNA-damage-inducible, beta FLJ00058 19p13.3 hypothetical protein FLJ00058 GNG7 19p13.3 guanine nucleotide binding protein (G protein), gamma 7 LOC390875 19 similar to fos39347_1 DIRAS1 19p13.3 DIRAS family, GTP-binding RAS-like 1 LOC388490 19 LOC388490 SLC39A3 19p13.3 solute carrier family 39 (zinc transporter), member 3 SGTA 19p13 small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha THOP1 19p13.3 thimet oligopeptidase 1 FLJ34817 19p13.3 hypothetical protein FLJ34817 MGC26707 19p13.3 hypothetical protein MGC26707 FLJ11637 19p13.3 hypothetical protein FLJ11637 LOC126295 19p13.3 hypothetical protein LOC126295 ZNF77 19p zinc finger protein 77 (pT1) FLJ14009 19p13.3 transducin-like enhancer protein 6 TLE2 19p13.3 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) AES 19p13.3 amino-terminal enhancer of split GNA11 19p13.3 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) LOC390876 19 similar to ribosomal protein L35 GNA15 19p13.3 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) LOC388491 19 similar to KIAA1683 protein EDG6 19p13.3 endothelial differentiation, G-protein-coupled receptor 6 LOC56926 19p13.3 hypothetical protein from EUROIMAGE 2021883 BRUNOL5 19p13 bruno-like 5, RNA binding protein (Drosophila) NFIC 19p13.3 nuclear factor I/C (CCAAT-binding transcription factor) LOC284422 19p13.3 similar to HSPC323 MGC4293 19p13.3 hypothetical protein MGC4293 FZR1 19p13.3 hypothetical protein MGC4293 LOC388492 19 LOC388492 MGC20700 19p13.3 hypothetical protein MGC20700 HMG20B 19p13.3 high-mobility group 20B GIPC3 19p13.3 PDZ domain protein GIPC3 LOC388493 19 similar to putative protein (5J182) TBXA2R 19p13.3 thromboxane A2 receptor PIP5K1C 19p13.3 phosphatidylinositol-4-phosphate 5-kinase, type I, gamma TJP3 19p13.3 tight junction protein 3 (zona occludens 3)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1615 - 359 - 2009 19332487
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   moderately
Nervousbrain   highly
Reproductivemale systemprostate  moderately
Respiratorylung   highly
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GTPase domain with three regions named switches 1, 2 and 3 and including the sites for guanine nucleotide binding and effector interaction
  • an helical domain
  • HOMOLOGY
    intraspecies paralog to GNAQ
    Homologene
    FAMILY
  • G-alpha family
  • G(q) subfamily
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • mediating pertussis toxin-resistant stimulation of phospholipase C beta
  • involved as modulators or transducers in various
  • transmembrane signaling systems
  • involved in signaling of gonadotropin-releasing hormone receptor, which negatively regulates cell growth
  • acting as an activator of phospholipase C
  • endothelial GNAQ/GNA11-mediated signaling as a critical mediator of fatal systemic anaphylaxis
  • GNAQ and GNA11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes
  • contribute to T lymphocyte migration by promoting turnover of integrin ITGAL through recycling
  • GNA11 and GNA14 induce changes in cellular morphology and growth-factor independence via MAPK activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
  • KISS1R regulates ERK1/2 activity and hypothalamic gene expression in a GNAQ/GNA11 and ARRB-dependent manner
  • ADRBK1 selectively interacts with GNAQ/GNA11 family that are released during G protein-coupled receptor activation
  • cell & other
    REGULATION
    Phosphorylated by PRKC and CAMK1 contributing to agonist-induced homologous desensitization of HTR2A signaling as well as heterologous desensitization
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer
    tumoral somatic mutation      
    in uveal melanoma
    tumoral somatic mutation      
    in primary melanocytic tumours of the CNS, GNA11 and NRAS mutations represent a mechanism of MAPK pathway activation alternative to the common GNAQ mutations( :
    tumoral somatic mutation     gain of function
    in iris melanomas
    Susceptibility to uveal melanoma, and rapidly involuting congenital hemangioma [RICH] or non-involuting congenital hemangioma [NICH]
    Variant & Polymorphism other
  • Glu209 GNAQ and GNA11 missense variants we identified are common in uveal melanoma, and in rapidly involuting congenital hemangioma [RICH] or non-involuting congenital hemangioma [NICH]
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergy  
    potential new target to prevent or treat anaphylactic reactions
    ANIMAL & CELL MODELS