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FLASH GENE
Symbol GMPS contributors: npt/mct - updated : 10-01-2009
HGNC name guanine monophosphate synthetase
HGNC id 4378
Location 3q24      Physical location : 155.588.324 - 155.655.518
Synonym name
  • glutamine amino transferase
  • GMP synthase [glutamine-hydrolyzing]
  • glutamine amidotransferase
  • guanosine 5'-monophosphate synthase
  • glutamine-hydrolyzing
  • MLL/GMPS fusion protein
  • Synonym symbol(s) D3S4088, GMPS-PEN
    EC.number 6.3.5.2
    DNA
    TYPE functioning gene
    STRUCTURE 6.72 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    AADAC 3q21.3-q25.2 arylacetamide deacetylase (esterase) GPR91 3q24-3q25.1 G protein-coupled receptor 91 MBNL1 3q25.1-q25.2 muscleblind-like (Drosophila) P2RY1 3q25 purinergic receptor P2Y, G-protein coupled, 1 RAP2B 3q25.2 RAP2B, member of RAS oncogene family LOC152118 3q25.2 hypothetical gene supported by AF086445 DKFZP434D146 3q25.2 DKFZP434D146 protein RH_II/GuBp2 3q25.2 similar to orphan seven transmembrane receptor DHX36 3q25 DEAH (Asp-Glu-Ala-His) box polypeptide 36 GPR149 3q25.2 G protein-coupled receptor 149 MME 3q25.1-q25.2 membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) LOC256283 3q25.2 hypothetical LOC256283 KIAA1069 3q26.1 hypothetical LOC256283 FLJ31139 3q25.31 hypothetical protein FLJ31139 SLC33A1 3q25.31 solute carrier family 33 (acetyl-CoA transporter), member 1 GMPS 3q24 guanine monphosphate synthetase LOC389168 3 similar to template acyivating factor-I alpha LOC344760 3q25.31 similar to seven transmembrane helix receptor MRE11B 3q25 MRE11 meiotic recombination 11 homolog B (S. cerevisiae) KCNAB1 3q26.1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 SSR3 3q25.31 signal sequence receptor, gamma (translocon-associated protein gamma) TIPARP 3q25.31 TCDD-inducible poly(ADP-ribose) polymerase LOC389169 3 hypothetical gene supported by BC001951; NM_006191 LOC389170 3 similar to hypothetical protein FLJ14957 LOC339892 3q25.31 similar to Death domain containing protein CRADD (Caspase and RIP adaptator with death domain) (RIP associated protein with a death domain) CCNL1 3q26.1 cyclin L1 LOC391589 3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) FLJ12604 3q24-q25 hypothetical protein FLJ12604 PTX3 3q21-q25 pentaxin-related gene, rapidly induced by IL-1 beta LOC152078 3q25.32 hypothetical protein BC010062 SHOX2 3q25-q26.1 short stature homeobox 2 MGC12197 3q25.32 BM-011 protein MLF1 3q25.1 myeloid leukemia factor 1 EFG1 3q25.1-q26.2 myeloid leukemia factor 1 LXN 3q25-q31 myeloid leukemia factor 1 RARRES1 3q25.31 retinoic acid receptor responder (tazarotene induced) 1 FLJ14153 3q25.32 hypothetical protein FLJ14153 GPR79 3q26 G protein-coupled receptor 79 pseudogene SCHIP1 3q25.3-q27 schwannomin interacting protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2457 76.7 693 - Pegram (2000)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
     spinal cord   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal glutamine amidotransferase (GAT)
  • GMP synthase C terminal domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans m106.4
    Homologene
    FAMILY
  • glutamine amidotransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis
  • USP7-GMPS complex catalyzed the selective deubiquitylation of histone H2B, but not H2A
  • can regulate the activity of a ubiquitin protease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component complexing with USP7
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    wiyh MLL in t(3;11)(q25;q23)in acute myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS