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FLASH GENE
Symbol GMPR contributors: - updated : 18-06-2004
HGNC name guanosine monophosphate reductase
HGNC id 4376
Location 6p23      Physical location : 16.238.810 - 16.295.778
Synonym symbol(s) GMPR1
EC.number 1.6.6.8
DNA
TYPE functioning gene
STRUCTURE 57.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure two potential SP1 binding sites within exon 1
MAPPING cloned Y linked N status confirmed
Physical map
CD83 6p23 CD83 antigen (activated B lymphocytes, immunoglobulin superfamily) JMJ 6p24-p23 jumonji homolog (mouse) DTNBP1 6p22.3 dystrobrevin binding protein 1 LOC346113 6p22.3 similar to ARP2/3 complex 21 kDa subunit (p21-ARC) (Actin-related protein 2/3 complex subunit 3) LOC391871 6 similar to malate dehydrogenase 1; malate dehydrogenase, soluble; Malate dehydrogenase-like enzyme MYLIP 6p23-p22.3 myosin regulatory light chain interacting protein MRPL42P2 6p22.3 myosin regulatory light chain interacting protein GMPR 6p23 guanosine monophosphate reductase SCA1 6p23 spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1) RNPC6 6p22.3 RNA-binding region (RNP1, RRM) containing 6 CAP2 6p22.3 CAP, adenylate cyclase-associated protein, 2 (yeast) FAM8A1 6p23 family with sequence similarity 8, member A1 NUP153 6p25.3-p22.1 nucleoporin 153kDa KIF13A 6p23 kinesin family member 13A NHLRC1 6p22.3 NHL repeat containing 1 TPMT 6p22.3 thiopurine S-methyltransferase AOF1 6p22.3 amine oxidase, flavin containing 1 DEK 6p23 DEK oncogene (DNA binding) LOC391872 6 similar to ATP-dependent RNA helicase DDX18 (DEAD-box protein 18) (Myc-regulated DEAD-box protein) (MrDb) LOC391873 6 similar to inosine monophosphate dehydrogenase 1 isoform b; sWSS2608 IBRDC2 6p22.3 IBR domain containing 2
RNA
TRANSCRIPTS type messenger
text at least two different alleles are known; a functional,atypical polyadenylation signal in exon 9
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Reproductivefemale systembreastmammary gland  
Skin/Tegumentskin    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies homolog to rattus Gmpr
homolog to murine Gmpr
homolog to C.elegans F32d1.5
intraspecies homolog to GMPR2
Homologene
FAMILY IMPDH/GMPR family.
CATEGORY enzyme , immunity/defense
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • faciliting thermogenesis
  • functioning in the conversion of nucleoobase,nucleoside and nucleotide derivatives of G to A nucleotides
  • maintening the intracellular balance of A and G nucleotides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    purine metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS