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FLASH GENE
Symbol GMNC contributors: mct - updated : 09-05-2012
HGNC name geminin coiled-coil domain containing
HGNC id
Location 3q28      Physical location : -
Synonym name
  • geminin coiled-coil containing protein 1
    • Synonym symbol(s) GEMC1, DKFZp434B153, DKFZp781J1746
    DNA
    TYPE functioning gene
    STRUCTURE 9.94 kb     5 Exon(s)
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3624 - 334 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY Geminin superfamily
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for chromosomal DNA replication
  • promotes initiation of chromosomal DNA replication in multicellular organisms by mediating TOPBP1- and CDK2-dependent recruitment of CDC45 onto replication origins
  • implicated in the cell cycle and is required for DNA replication
  • MCI, GMNN, and GMNC may have arisen in vertebrates through duplication of an ancestral Geminin-like gene
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with TOPBP1 and is a rate-limiting cyclin-dependent kinase target
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS