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FLASH GENE
Symbol GMEB2 contributors: - updated : 10-09-2005
HGNC name glucocorticoid modulatory element binding protein 2
HGNC id 4371
Location 20q13.33      Physical location : 62.218.954 - 62.258.381
Synonym name
  • rat glucocorticoid modulatory element binding protein homolog
  • parvovirus initiation factor, p79
  • Synonym symbol(s) KIAA1269, PIF79, P79PIF
    DNA
    TYPE functioning gene
    STRUCTURE 32.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Endocrinepancreas   highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systembreastmammary gland  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal KDWK domain, necessary for DNA binding
  • a SAND (DNA binding) domain
  • a highly acidic C terminus that likely forms a coiled-coil structure
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus glucocorticoid modulatory element binding protein
    intraspecies homolog to GMEB1
    Homologene
    FAMILY KDWK family of proteins
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • modulator of transactivation by the glucocorticoid receptor, essential for parvovirus DNA replication
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of GMEB1 and GMEB2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding glucocorticoid receptor modulatory elements
  • may interact with CREB- binding protein (CBP)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS