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FLASH GENE
Symbol GMEB1 contributors: mct - updated : 08-02-2011
HGNC name glucocorticoid modulatory element binding protein 1
HGNC id 4370
Location 1p35.3      Physical location : 28.995.243 - 29.041.385
Synonym name
  • rat glucocorticoid modulatory element binding protein homolog
  • DNA-binding protein p96PIF
  • parvovirus initiation factor p96
  • Synonym symbol(s) P96PIF, PIF96
    DNA
    TYPE functioning gene
    STRUCTURE 46.16 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DJ159A19.3 1p36.13 hypothetical protein DJ159A19.3 LOC388612 1 LOC388612 FGR 1p35 Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog G1P3 1p35 interferon, alpha-inducible protein (clone IFI-6-16) LOC339409 1p35.3 similar to Procollagen (type III) N-endopeptidase MGC34648 1p35.3 hypothetical protein MGC34648 STX12 1p35-p34.1 syntaxin 12 PPP1R8 1p35 protein phosphatase 1, regulatory (inhibitor) subunit 8 C1orf38 1p35.2 chromosome 1 open reading frame 38 RPA2 1p35 replication protein A2, 32kDa ASML3B 1p35.2 acid sphingomyelinase-like phosphodiesterase FLJ10307 1p35.2 hypothetical protein FLJ10307 EYA3 1p36 eyes absent homolog 3 (Drosophila) LOC388613 1 similar to Microsomal signal peptidase 25 kDa subunit (SPase 25 kDa subunit) (SPC25) LOC391024 1 similar to RIKEN cDNA 2610313E07 PTAFR 1p35.1-p34.3 platelet-activating factor receptor DNAJC8 1p35.3 DnaJ (Hsp40) homolog, subfamily C, member 8 ATPIF1 1p35.3 ATPase inhibitory factor 1 SESN2 1p35.3 sestrin 2 FLJ20045 1p35.2 TRAP/mediator complex subunit p28b FLJ13171 1p35 TRAP/mediator complex subunit p28b CHC1 1p36.1 chromosome condensation 1 SECP43 1p35.2 tRNA selenocysteine associated protein LOC85028 1p35.2 PNAS-123 MGC45806 1p35.2 hypothetical protein MGC45806 TAF12 1p35.2 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa GMEB1 1p35.2 glucocorticoid modulatory element binding protein 1 HGRG8 14q12-q21 high-glucose-regulated protein 8 OPRD1 1p36.1-p34.3 opioid receptor, delta 1 EPB41 1p36.1-p35 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) LOC90719 1p35.2 similar to KIAA1913 SFRS4 1p35.1-p34.3 splicing factor, arginine/serine-rich 4 CGI-63 1pter-p22.3 nuclear receptor binding factor 1 PTPRU 1pter-p35 protein tyrosine phosphatase, receptor type, U LOC391025 1 similar to protein tyrosine phosphatase, receptor type, U isoform 2 precursor; protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron; pi R-PTP-Psi
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1960 64 573 - 2000 10734202
    including exon 2
    10 splicing 1944 63 563 - 2000 10734202
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestine   
    Nervousganglia    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a region containing the sequence KDWK necessary for DNA binding
  • a SAND (DNA binding) domain
  • mono polymer homomer , heteromer , dimer , oligo
    HOMOLOGY
    interspecies homolog to rattus glucocorticoid modulatory element binding protein
    Homologene
    FAMILY
  • KDWK family of proteins
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • modulator of transactivation by the glucocorticoid receptor
  • essential for parvovirus DNA replication
  • attenuated the Fas-mediated activation of these caspases and the subsequent apoptosis
  • is potentially an endogenous regulator that selectively binds to initiator procaspases and inhibits caspase-induced apoptosis
  • functions as a potent inhibitor of caspase activation and apoptosis in response to oxidative stress
  • can blocks pro-apoptosis signals induced by a variety of stresses
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with GMEB2
  • INTERACTION
    DNA DNA binding
    RNA
    small molecule
    protein
  • binding glucocorticoid receptor modulatory elements
  • interacts with the prodomain of procaspase-2, thereby disrupting its autoactivation and the induction of apoptosis
  • interaction with procaspase-2, -8, or -9 prevents caspase oligomerization and maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS