basic FUNCTION
| being a key enzyme linking glutamate metabolism with the Krebs cycle |
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catalyzing the oxidative deamination of 1-glutamate to 2-oxoglutarate in the mitochondrial matrix |
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functioning in nervous system in both the synthesis and the catabolism of glutamate and perhaps in ammonia detoxification |
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may be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate |
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plays an essential role in the full development of the insulin secretory response |
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might contribute to the formation of specific synapses in the hippocampus such as those formed by the projecting neurons of the entorhinal cortex |
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catalyses the reversible inter-conversion of glutamate to alpha-ketoglutarate and ammonia, thus interconnecting amino acid and carbohydrate metabolism |
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participates in the breakdown and synthesis of glutamate, the main excitatory neurotransmitter |
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SIRT4 and GLUD1 overexpression play antagonistic roles in regulating gliogenesis |
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role for GLUD1, GLUD2 at excitatory synapses in neuronal networks throughout the adult brain |
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mitochondrial enzyme that catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia while reducing NAD+ and/or NADP+ to NADH and/or NADPH |
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GLUD1 and GlUD2 exhibit the molecular architecture of postsynaptic ionotropic glutamate receptors, but assemble into trans-synaptic adhesion complexes by binding to secreted cerebellins that in turn interact with presynaptic neurexins |