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FLASH GENE
Symbol GLRX5 contributors: np/mct - updated : 30-05-2018
HGNC name glutaredoxin 5
HGNC id 20134
Corresponding disease
ASPR2 sideroblastic anemia, pyridoxine-refractory 2
Location 14q32.13      Physical location : 96.001.322 - 96.011.055
Synonym name
  • chromosome 14 open reading frame 87
  • glutaredoxin 5 homolog (S. cerevisiae)
  • glutaredoxin-related protein 5
  • monothiol glutaredoxin-5
    • Synonym symbol(s) FLJ34739, C14orf87, PR01238, GRX5, PRO1238, MGC14129
    DNA
    TYPE functioning gene
    STRUCTURE 9.73 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1182 - 157 - - 17485548
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer tetramer
    HOMOLOGY
    interspecies ortholog to murine Glrx5
    Homologene
    FAMILY glutaredoxin family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may be involved in Fe/S cluster assembly
  • mitochondrial monothiol glutaredoxin
  • function as a scaffold and may facilitate the transfer of Fe/S clusters to target apoproteins
  • may also provide Fe/S cofactor for ferrochelatase, the last enzyme in heme synthesis
  • has a direct role in the maintenance of normal cytosolic and mitochondrial iron homoeostasis, and its expression affects haem biosynthesis and erythropoiesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of BOLA1 with the mitochondrial monothiol glutaredoxin GLRX5 provides hints for potential mechanisms behind BOLA1's effect on mitochondrial redox potential
  • structural plasticity of the dimeric state of the [2Fe-2S] bound form of human GLRX5 (holo hGRX5) is the crucial factor that allows an efficient cluster transfer to the partner proteins ISCA1 and ISCA2 by a specific protein-protein recognition mechanism
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ASPR2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • hypochromic anemia in 'shiraz' (sir) zebrafish mutants is caused by deficiency of grx5
  • zebrafish grx5 rescued the assembly of grx5 yeast Fe-S, showing that the biochemical function of grx5 is evolutionarily conserved