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FLASH GENE
Symbol GLRX3 contributors: SGE - updated : 04-06-2008
HGNC name glutaredoxin 3
HGNC id 15987
Location 10q26.3      Physical location : 131.934.662 - 131.977.870
Synonym name
  • PKC-interacting cousin of thioredoxin
  • thioredoxin-like 2
  • glutaredoxin 4
  • PKC-theta-interacting protein
  • protein kinase C-interacting cousin of thioredoxin
  • Synonym symbol(s) PICOT, bA500G10.4, GRX3, GLRX4, GRX4, TXNL2, FLJ11864, TXNL3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 43.21 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1274 37 335 - -
    - - 1365 - 335 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveliver    
    Reproductivefemale systemuteruscervix highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectiveadipose  highly
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal tioredoxin homology domain
  • two tandem repeats of a domain highly conserved from plants to mammals
  • conjugated MetalloP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Txnl2
    Homologene
    FAMILY
  • thioredoxin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text colocalizes with CSRP3 in the Z-disc
    basic FUNCTION
  • regulator of thioderoxin system
  • may act as an endogenous negative feedback regulator of cardiac hypertrophy through its ability to inhibit PKC activity, which is elevated during cardiac hypertrophy
  • inhibiting cardiac remodeling by with a concomitant increase in ventricular function and cardiomyocyte contractility
  • inhibit pressure overload-induced cardiac hypertrophy, concomitant with an increase in ventricular function and cardiomyocyte contractility
  • inhibits cardiac hypertrophy largely by negatively regulating calcineurin-NFAT signaling via disruption of the CSRP3-calcineurin interaction
  • protein invovled in the regulation of signal transduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • iron-sulfur protein
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binding 2 bridging [2Fe-2S] clsuters in a homodimeric complex
  • protein
  • protein kinase C
  • inhibiting the c Jun N terminal kinase/AP-1 and Nekappa B pathway
  • directly interacts with CSRP3 via its C-terminal half (PICOT-C) (colocalizes with CSRP3 in the Z-disc, and CSRP3 is known to play a role in anchoring calcineurin to the Z-disc in the sarcomere and is critical for calcineurin-NFAT signaling)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased the ventricular function and cardiomyocyte contractility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularcardiomyopathy 
    may provide an efficient modality for treatment of cardiac hypertrophy and heart failure
    ANIMAL & CELL MODELS