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FLASH GENE
Symbol GLRX2 contributors: - updated : 04-10-2006
HGNC name glutaredoxin 2
HGNC id 16065
Location 1q31.2-q31.3      Physical location : 193.065.599 - 193.075.244
Synonym symbol(s) GRX2
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
DBCCR1L 1q25.3 DBCCR1-like RGS18 1q31,2 regulator of G-protein signalling 18 LOC220672 1q31.1 similar to ATP-binding cassette sub-family E member 1 (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) (HuHP68) LOC164036 1q31.1 similar to implantation-related RGS2-like protein RGS1 1q31 regulator of G-protein signalling 1 RGS13 1q25-3 regulator of G-protein signalling 13 LOC388720 1 similar to bA92K2.2 (similar to ubiquitin) RGS2 1q31 regulator of G-protein signalling 2, 24kDa LOC388721 1 LOC388721 LOC391146 1 similar to zinc finger protein 12 UCHL5 1q32 ubiquitin carboxyl-terminal hydrolase L5 SSA2 1q32 Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen SS-A/Ro) GLRX2 1q31.2-q31.3 glutaredoxin 2 C1orf28 1q25-q31 chromosome 1 open reading frame 28 B3GALT2 1q31 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 LOC343448 1q31.1 similar to elongation factor 1 alpha SLICK 1q31.2 sodium- and chloride-activated ATP-sensitive potassium channel
RNA
TRANSCRIPTS type messenger
text alternative splicing forms identified that differed in sequences upstream of exon 2
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1170 - 165 mitochondrial Lundberg, Lillig
  • functional N terminal mitochondrial translocation signal
  • catalyzing glutathione-dependent dithiol reaction mechanisms, reducing protein disulfides, and monothiol reactions, reducing mixed disulfides between proteins and GSH (de-/glutathionylation)
  • - splicing 735 18 164 nuclear Lillig
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrineadrenal gland    
    Nervousbrain    
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a mitochondrial signal peptide
  • a dithriol/disulfide active site containing the Cys-Ser-Tyr-Cys motif and the GSH binding site
  • mono polymer homomer , monomer , dimer
    HOMOLOGY
    interspecies homolog to murine Gbrx2
    ortholog to C.elegans
    Homologene
    FAMILY
  • glutaredoxin family
  • thioredoxin fold superfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text predominantly in the nucleus but also in the mitochondria
    basic FUNCTION
  • iron-sulfur protein, functioning as an electron carrier in glutathione-dependent synthesis of dNTPs by ribonucleotide reductase
  • glutathione-dependent oxidoreductase (active site: Cys-Ser-Tyr-Cys)facilitating the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress
  • facilitating the maintenance of cellular redox homeostasis upon treatment with apoptotic agents, thereby preventing cardiolipin oxidation and cytochrome C release
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
  • monomer is active form
  • homodimer is inactive form and probably linked by 1
  • 2Fe-2S cluster
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by iodoacetamide and H2O2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    decreases the susceptibility to apoptosis andprevents loss of cardiolipin and cytochrome C release
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS