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FLASH GENE
Symbol GLP1R contributors: mct/npt - updated : 23-04-2012
HGNC name glucagon-like peptide 1 receptor
HGNC id 4324
Location 6p21      Physical location : 39.016.556 - 39.055.519
Synonym name GLP-1 receptor
Synonym symbol(s) MGC138331, GLP-1-R, GLP-1R
DNA
TYPE functioning gene
STRUCTURE 38.90 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3123 53 463 - Tornehave (2008)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly Homo sapiens
Endocrinepancreas     Homo sapiens
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
Endocrineislet cell (alpha,beta...) Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor, secretin family, coupling with Gs alpha protein and activating adenylate cyclase
  • N-terminal extracellular domain (nGLP-1R) is a ligand binding domain with differential affinity for Ex4 and GLP1 (Runge 2007)
    • conjugated sumoylated
    HOMOLOGY
    Homologene
    FAMILY
  • class B family of 7-transmembrane-spanning, heterotrimeric
  • G protein-coupled receptors
    • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating the insulinotropic effect of the incretin hormone GLP1
  • involved in learning, memory and neuroprotection
  • role for the GLP1R in endogenous glucose production
  • GLP1R, GIPR, and GCGR internalize with differential properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SUMO modification of the GLP1R could be a contributing factor to reduced incretin responsiveness
  • cross-talk between the two incretin receptors GLP1R and GIPR is shown to alter receptor trafficking with functional consequences for GLP1R signaling
    • cell & other
    REGULATION
    Other regulated by SP1 and SP3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gut and lung neuroendocrine tumors--in particular, in insulinomas (Korner 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    novel molecular target for in vivo scintigraphy and targeted radiotherapy for a variety of GLP1 receptor-expressing tumors
    neurologyneurodegenerativeParkinson/dementia Parkinsonism
    GLP1R agonists (Exendin4) may exert various useful actions in persons at high risk for stroke or with Parkinson disease, a hypothesis that is amenable to clinical testing
    cardiovascularatheroma 
    GLP1R agonists seem to have direct effects on the cells involved in the progression of atherosclerosis, such as endothelial cells or macrophages
    miscelleaneousvascularischemic injury
    EX4, GLP1R agonists reduced intimal thickening after vascular injury
    diabetetype 2 
    GLP1R agonists may help design new therapies for cardiovascular disease in patients with type 2 diabetes
    ANIMAL & CELL MODELS