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FLASH GENE
Symbol GLIS2 contributors: mct/pgu - updated : 31-08-2010
HGNC name GLIS family zinc finger 2
HGNC id 29450
Corresponding disease
NPHP7 nephronophthisis 7
Location 16p13.3      Physical location : 4.382.224 - 4.389.598
Synonym name
  • Kruppel-like zinc finger protein GLIS2
  • GLI-related, Kruppel-like zinc finger protein 2
  • Gli-similar 2
  • neuronal Krueppel-like protein
  • kruppel-like zinc finger protein GLIS2
  • Synonym symbol(s) FLJ38247, NKL
    DNA
    TYPE functioning gene
    STRUCTURE 7.38 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ZNF174 16p13.3 zinc finger protein 174 FLJ33071 16p13.3 hypothetical protein FLJ33071 LOC388207 16 LOC388207 FLJ14154 16p13.3 hypothetical protein FLJ14154 LOC390671 16 similar to ribosomal protein L18; 60S ribosomal protein L18 KIAA0643 16p13.3 similar to ribosomal protein L18; 60S ribosomal protein L18 NOD3 16p13.3 NOD3 protein BTBD12 16p13.3 BTB (POZ) domain containing 12 LOC283877 16p13.3 hypothetical LOC283877 DNASE1 16p13.3 deoxyribonuclease I TRAP1 15q25-q26 tumor rejection antigen (gp96) pseudogene 1 CREBBP 16p13.3 CREB binding protein (Rubinstein-Taybi syndrome) ADCY9 16p13.3 adenylate cyclase 9 LOC388208 16 LOC388208 SRL 16p13.3 sarcalumenin TFAP4 16p13 transcription factor AP-4 (activating enhancer binding protein 4) GLIS2 16p13.3 Kruppel-like zinc finger protein GLIS2 Magmas 16p13.3 mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction FLJ22021 16p13.3 hypothetical protein FLJ22021 DNAJA3 16p13.3 DnaJ (Hsp40) homolog, subfamily A, member 3 HSCARG 16p13.3 HSCARG protein HMOX2 16p13.3 heme oxygenase (decycling) 2 C16orf5 16p13.3 heme oxygenase (decycling) 2 LOC342346 16p13.3 similar to hypothetical protein DKFZp434P0316 LOC124402 16p13.3 LOC124402 MGRN1 16p13 mahogunin, ring finger 1 SDOS 16p13.3 hypothetical protein MGC11275 LOC146562 16p13.3 hypothetical protein AF447587 ZNF500 16p13.3 zinc finger protein 500 FLJ25410 16p13.3 hypothetical protein FLJ25410 LOC388209 16 hypothetical gene supported by BC022385; BC035868; BC048326 FLJ22386 16p13.3 leucine zipper domain protein N-PAC 16p13.3 cytokine-like nuclear factor n-pac UBN1 16p13.3 ubinuclein 1 PPL 16p13.3 periplakin KIAA0420 16p13.3 periplakin NAGPA 16p13.3 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase MGC45438 16p13.3 hypothetical protein MGC45438 ALG1 16p13.3 asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3705 - 524 - 2007 17344476
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Endocrinepancreas   moderately Homo sapiens
    Urinarykidney   predominantly Homo sapiens
    Visualeyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • five C2H2-type zinc fingers
  • HOMOLOGY
    Homologene
    FAMILY
  • subfamily of Krüppel-like zinc finger transcriptional regulators that are related to Gli and Zic proteins
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • ciliary expression
  • GLIS2 and GLIS3 proteins have been demonstrated to localize to the primary cilium, a signaling organelle that has been implicated in several pathologies, including cystic renal diseases
  • basic FUNCTION
  • required for the normal development of the posterior half of each embryonic segment
  • may be playing a role in the regulation of certain kidney functions and during embryonic development (through activation and repressor function)
  • having an essential role for the maintenance of renal tissue architecture through prevention of apoptosis and fibrosis
  • required for the maintenance of normal kidney tissue architecture and function through prevention of apoptosis and fibrosis
  • involved in neuronal differentiation, whereas the cleaved form requires coexpression of CTNND1 to have a similar effect
  • plays a critical role in the maintenance of normal kidney architecture and functions
  • can function as a transcriptional activator and that post-translational modification within its DNA-binding domain can regulate its transcriptional activity
  • can function as an activator of transcription and that its activity can be modulated by post-translational modifications
  • plays a critical role in the maintenance of normal renal functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text kidney developement, neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds effectively to the consensus Glis binding sequence (GlisBS) (G/C)TGGGGGGT(A/C)
    RNA
    small molecule
    protein
  • binding protein for CTNND1
  • interact with CTBP1 (repressed transcriptional activation induced by GLIS2)
  • cell & other
    REGULATION
    Other regulated by CTNND1 (induces the C-terminal cleavage of GLIS2, and this cleavage is further enhanced by SRC)
    ASSOCIATED DISORDERS
    corresponding disease(s) NPHP7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS