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FLASH GENE
Symbol GLIPR1 contributors: mct - updated : 27-08-2013
HGNC name GLI pathogenesis-related 1 (glioma)
HGNC id 17001
Location 12q21.2      Physical location : 75.874.512 - 75.895.715
Synonym name
  • related to testis-specific, vespid, and pathogenesis proteins 1
  • glioma pathogenesis-related protein 1
  • related to testis-specific, vespid
  • Synonym symbol(s) GLIPR, RTVP1, CRISP7
    DNA
    TYPE functioning gene
    STRUCTURE 21.20 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text 3 predominant mRNAs of 4.2, 3.2, and 1.1 kb (Rich)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 3924 30 266 - 2011 22025562
    7 - 714 26.9 237 . preferentially expressed in the testis, ovary and peripheral blood cells . highly expressed in glioblastomas, whereas lower expression was observed in low-grade astrocytomas and oligodendrogliomas 2011 22025562
  • insertion of an exon
  • may be used as a prognostic marker and a therapeutic target in gliomas
  • increased cell proliferation, but it did not affect glioma cell migration
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveliver   lowly
     salivary gland   highly
     stomach   highly
    Reproductivemale systemprostate   
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines glioblastoma multiform/astrocytoma
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney only
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide that directs its secretion
  • a conserved cysteine-rich CAP (cysteine-rich secretory proteins, antigen 5 and pathogenesis-related 1 proteins) domain
  • a transmembrane domain
  • HOMOLOGY
    intraspecies homolog to testis-specific protein, TPX1
    Homologene
    FAMILY CRISP family, CAP superfamily
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • having proapoptotic activities in prostate and bladder cancer cells
  • suppresses prostate cancer development through targeted oncoprotein destruction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein TP53 target gene
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    through gene methylation in prostate cancer
    tumoral     --other  
    expressed in astrocytic tumors and its expression is correlated with tumor grade
    tumoral     --low  
    methylation-silenced gene in the acute myeloid leukemia (AML)patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target RTVP1b represents a potential prognostic marker and therapeutic target in gliomas
    ANIMAL & CELL MODELS