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FLASH GENE
Symbol GLIPR1 contributors: mct - updated : 27-08-2013
HGNC name GLI pathogenesis-related 1 (glioma)
HGNC id 17001
Location 12q21.2      Physical location : 75.874.512 - 75.895.715
Synonym name
  • related to testis-specific, vespid, and pathogenesis proteins 1
  • glioma pathogenesis-related protein 1
  • related to testis-specific, vespid
    • Synonym symbol(s) GLIPR, RTVP1, CRISP7
    DNA
    TYPE functioning gene
    STRUCTURE 21.20 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC23401 12q15 hypothetical protein MGC23401 DKFZP564I0422 12q15 hypothetical protein DKFZp564I0422 FLJ10936 12q15 hypothetical protein FLJ10936 RAB21 12q13.3 RAB21, member RAS oncogene family FLJ12085 TPH2 12q15 tryptophan hydroxylase 2 TRHDE 12q15-q21 Homo sapiens thyrotropin-releasing hormone degrading ectoenzyme (TRHDE), mRNA. VENTX2P3 12q15 VENT-like homeobox 2 pseudogene 3 LOC387869 12 LOC387869 LOC390343 12 similar to microtubule-associated proteins 1A/1B light chain 3 KCNC2 19q13.4 potassium voltage-gated channel, Shaw-related subfamily, member 2 CAPS2 12q21.1 calcyphosphine 2 MGC26856 12q21.1 hypothetical protein MGC26856 MGC39497 12q21.1 hypothetical protein MGC39497 GLIPR1 12q21.1 GLI pathogenesis-related 1 (glioma) HRB2 12q21.1 HIV-1 rev binding protein 2 LOC390344 12 similar to 6-phosphogluconate dehydrogenase, decarboxylating LOC390345 12 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) PHLDA1 12q15 pleckstrin homology-like domain, family A, member 1 NAP1L1 12q15 nucleosome assembly protein 1-like 1 LOC121071 12q21.1 similar to NOGO-interacting mitochondrial protein FLJ23560 12q21.1 hypothetical protein FLJ23560 OSBPL8 12q14 oxysterol binding protein-like 8 LOC123031 12q21.1 similar to 60S ribosomal protein L21 HIP14 12q14-q15 similar to 60S ribosomal protein L21 CSRP2 12q21.1 cysteine and glycine-rich protein 2 LOC390346 12 similar to Ran-specific GTPase-activating protein (Ran binding protein 1) (RanBP1) E2F7 12q21.1 E2F transcription factor 7 NAV3 12q21.1 neuron navigator 3 MRPL11P3 12q21.2 neuron navigator 3 LOC390347 12 similar to ras related v-ral simian leukemia viral oncogene homolog A
    RNA
    TRANSCRIPTS type messenger
    text 3 predominant mRNAs of 4.2, 3.2, and 1.1 kb (Rich)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 3924 30 266 - 2011 22025562
    7 - 714 26.9 237 . preferentially expressed in the testis, ovary and peripheral blood cells . highly expressed in glioblastomas, whereas lower expression was observed in low-grade astrocytomas and oligodendrogliomas 2011 22025562
  • insertion of an exon
  • may be used as a prognostic marker and a therapeutic target in gliomas
  • increased cell proliferation, but it did not affect glioma cell migration
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveliver   lowly
     salivary gland   highly
     stomach   highly
    Reproductivemale systemprostate   
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines glioblastoma multiform/astrocytoma
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney only
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide that directs its secretion
  • a conserved cysteine-rich CAP (cysteine-rich secretory proteins, antigen 5 and pathogenesis-related 1 proteins) domain
  • a transmembrane domain
    • HOMOLOGY
    intraspecies homolog to testis-specific protein, TPX1
    Homologene
    FAMILY CRISP family, CAP superfamily
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • having proapoptotic activities in prostate and bladder cancer cells
  • suppresses prostate cancer development through targeted oncoprotein destruction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein TP53 target gene
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    through gene methylation in prostate cancer
    tumoral     --other  
    expressed in astrocytic tumors and its expression is correlated with tumor grade
    tumoral     --low  
    methylation-silenced gene in the acute myeloid leukemia (AML)patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target RTVP1b represents a potential prognostic marker and therapeutic target in gliomas
    ANIMAL & CELL MODELS