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FLASH GENE

Symbol

GLIPR1

contributors: mct - updated : 27-08-2013

HGNC name	GLI pathogenesis-related 1 (glioma)
HGNC id	17001

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q21.2      Physical location : 75.874.512 - 75.895.715
Synonym name	related to testis-specific, vespid, and pathogenesis proteins 1
	glioma pathogenesis-related protein 1
	related to testis-specific, vespid
Synonym symbol(s)	GLIPR, RTVP1, CRISP7

DNA

TYPE	functioning gene
STRUCTURE	21.20 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	3 predominant mRNAs of 4.2, 3.2, and 1.1 kb (Rich)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006851 6 splicing 3924 NP_006842 30 266 - 2011 22025562 RTVP1b 7 - 714 26.9 237 . preferentially expressed in the testis, ovary and peripheral blood cells . highly expressed in glioblastomas, whereas lower expression was observed in low-grade astrocytomas and oligodendrogliomas 2011 22025562 insertion of an exon may be used as a prognostic marker and a therapeutic target in gliomas increased cell proliferation, but it did not affect glioma cell migration

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Digestive liver       lowly   salivary gland       highly   stomach       highly Reproductive male system prostate       Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cell lineage
cell lines	glioblastoma multiform/astrocytoma
fluid/secretion

at STAGE

physiological period

fetal

Text	kidney only

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide that directs its secretion
	a conserved cysteine-rich CAP (cysteine-rich secretory proteins, antigen 5 and pathogenesis-related 1 proteins) domain
	a transmembrane domain

HOMOLOGY

intraspecies

homolog to testis-specific protein, TPX1

Homologene

FAMILY

CRISP family, CAP superfamily

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	having proapoptotic activities in prostate and bladder cancer cells
	suppresses prostate cancer development through targeted oncoprotein destruction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

TP53 target gene

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   through gene methylation in prostate cancer tumoral     --other   expressed in astrocytic tumors and its expression is correlated with tumor grade tumoral     --low   methylation-silenced gene in the acute myeloid leukemia (AML)patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	RTVP1b represents a potential prognostic marker and therapeutic target in gliomas

ANIMAL & CELL MODELS