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FLASH GENE
Symbol GLG1 contributors: mct - updated : 11-04-2013
HGNC name golgi apparatus protein 1
HGNC id 4316
Location 16q23.1      Physical location : 74.481.327 - 74.641.042
Synonym name
  • membrane sialoglycoprotein of the Golgi apparatus
  • cysteine-rich fibroblast growth factor receptor
  • E-selectin ligand-1
  • Synonym symbol(s) CFR-1, ESL-1, MG160 , MG-160
    DNA
    TYPE functioning gene
    STRUCTURE 159.72 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388290 16 similar to protein 40kD LOC390740 16 similar to peptidylprolyl isomerase A (cyclophilin A) PSMD7 16q22.2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) LOC388291 16 LOC388291 LOC283922 16q22.3 hypothetical protein LOC283922 LOC388292 16 similar to NPIP-like protein LOC388293 16 similar to nuclear pore complex interacting protein LOC388294 16 similar to secretory protein LOC348174 LOC388295 16 LOC388295 GLG1 16q22-q23 golgi apparatus protein 1 FLJ10520 16q22.3 hypothetical protein FLJ10520 FLJ34389 16q22.3 hypothetical protein FLJ34389 FA2H 16q23 fatty acid 2-hydroxylase FLJ12270 16q22.3 hypothetical protein FLJ12270 ZNRF1 16q22.3 zinc and ring finger protein 1 LDHD 16q22.3 lactate dehydrogenase D ZFP1 16q22.3 zinc finger protein 1 homolog (mouse) CTRB1 16q23.1-q23.2 chymotrypsinogen B1 LOC390741 16 similar to 40S ribosomal protein S4, Y isoform LOC339102 16q22.3 similar to Chymotrypsinogen B precursor LOC146599 16q22.3 hypothetical LOC146599 BCAR1 16q22-q23 breast cancer anti-estrogen resistance 1 LOC388296 16 LOC388296 CFDP1 16q22.2-q22.3 craniofacial development protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 8267 - 1192 - 2005 15797922
    27 - 8300 - 1203 - 2005 15797922
  • GLG1
  • GLG1 and GLG2 are the products of a single gene, the mRNA of which can be processed by alternative splicing to generate two different transcripts encoding either GLG1 or GLG2
  • 26 - 9339 - 1179 - 2005 15797922
    - - - - 1227 - 2005 15797922
  • identical to GLG1 except with a unique 24-amino-acid extension at the C-terminus of its cytoplasmic domain
  • GLG1 and GLG2 are the products of a single gene, the mRNA of which can be processed by alternative splicing to generate two different transcripts encoding either GLG1 or GLG2
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Reproductivefemale systemovary   
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • proline-glutamine rich intraluminal domain
  • 16 cysteine-rich repeats
  • a single transmembrane segment (TM1)
  • a short conserved cytoplasmic tail
  • C-terminal region retains GLG1 in the Golgi apparatus
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus mg160 and Selel
    ortholog to murine Esl1 and Selel
    homolog to Xenopus Xl.7363
    homolog to Zebrafish Dr.12007
    homolog to Drosophila CG7190
    homolog to C.elegans F14E5.2
    Homologene
    FAMILY
    CATEGORY signaling growth factor , receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • type I membrane protein
  • its expression in the Golgi apparatus and on the plasma membrane is finely tuned through two distinct mechanisms for exhibiting different functions
  • basic FUNCTION
  • is the product of a single gene, the mRNA of which can be processed by alternative splicing to generate two different transcripts encoding either GLG1 or GLG2
  • GLG1, SELPLG and CD44 encompassed all endothelial-selectin ligand activity on neutrophils by using gene- and RNA-targeted loss of function
  • distinct and dynamic contributions of these three glycoproteins in selectin-mediated neutrophil adhesion and signaling
  • is involved in FGF18 signalling via FGFR3C
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to fibroblast growth factor and E selectin
  • novel regulatory mechanism for FGF18 signaling involving GLG1 and DLK1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in low-grade astrocytomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS