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FLASH GENE
Symbol GLDC contributors: mct - updated : 06-12-2016
HGNC name glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P)
HGNC id 4313
Corresponding disease
GCE2 glycine encephalopathy 2
NKH1 hyperglycinemia 1, non ketotic
Location 9p24.1      Physical location : 6.532.465 - 6.645.692
Synonym name
  • glycine cleavage system P protein
  • glycine decarboxylase pyridoxal-phosphate dependent 120kDa, P protein
    • Synonym symbol(s) GCSP, GCE, HYGN1
    EC.number 1.4.4.2
    DNA
    TYPE functioning gene
    STRUCTURE 113.23 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   ALU
    text structure rich in Alu repeats facilitating deletions
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 3820 120 1020 - 2006 16450403
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain    
     spinal cord    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY gcvP family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • catalyzing the first step of the glycine cleavage system
  • induces dramatic changes in glycolysis and glycine/serine metabolism, leading to changes in pyrimidine metabolism to regulate cancer cell proliferation (PMID;
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NKH1 , GCE2
    related resource MITOP database
    Susceptibility
  • to neural tube defects
    • Variant & Polymorphism other
  • a splice acceptor site mutation and five different non-synonymous variants in GLDC, which were found to significantly impair enzymatic activity and represent putative causative mutations, predisposing to neural tube defects
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS