Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GLCE contributors: mct/npt - updated : 23-06-2010
HGNC name glucuronic acid epimerase
HGNC id 17855
Location 15q23      Physical location : 69.452.972 - 69.564.544
Synonym name
  • D-glucuronyl C5-epimerase
  • UDP-glucuronic acid epimerase
  • heparan sulfate epimerase
  • heparin/heparan sulfate-glucuronic acid C5-epimerase
  • Synonym symbol(s) KIAA0836, HSEPI
    EC.number 5.1.3.12
    DNA
    TYPE functioning gene
    STRUCTURE 111.57 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MADH3 15q21-q22 MAD, mothers against decapentaplegic homolog 3 (Drosophila) DKFZP586N0721 15q22.31 DKFZP586N0721 protein FLJ11506 15q22.31 hypothetical protein FLJ11506 FLJ12476 15q22.31 hypothetical protein FLJ12476 LOC145853 15q22.31 similar to ENSANGP00000021391 MAP2K5 15q22.2-q22.31 mitogen-activated protein kinase kinase 5 LOC390598 15 similar to RIKEN cDNA C230094B15 LOC388129 15 hypothetical gene supported by BC033162 LOC390599 15 similar to 40S ribosomal protein S15a PIAS1 15q21.3-q22.1 protein inhibitor of activated STAT, 1 MGC4809 15q22.2 serologically defined breast cancer antigen NY-BR-20 CLN6 15q23 ceroid-lipofuscinosis, neuronal 6, late infantile, variant FEM1B 15q22 fem-1 homolog b (C. elegans) ITGA11 15q22.3-q23 integrin, alpha 11 CORO2B 15q22-q23 coronin, actin binding protein, 2B ANP32A 15q22-q23 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A FLJ11722 15q22.31 hypothetical protein FLJ11722 LOC390600 15 similar to RIKEN cDNA 2810413N20 NOX5 15q22.31 NADPH oxidase, EF hand calcium-binding domain 5 SPESP1 15q22.31 sperm equatorial segment protein 1 FLJ33768 15q22.31 hypothetical protein FLJ33768 GLCE 15q22.31 glucuronyl C5-epimerase MPRG 15q22.31 glucuronyl C5-epimerase KIF23 15q22-q23 kinesin family member 23 RPLP1 15q22 ribosomal protein, large, P1 LOC388130 15 LOC388130 LOC388131 15 LOC388131 TLE3 15q22 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) UACA 15q22-q24 uveal autoantigen with coiled-coil domains and ankyrin repeats LOC123397 15q22.32 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) FLJ11196 15q22.32 acheron LOC390601 15 similar to keratin 8, type II cytoskeletal - human THAP10 15q22.32 THAP domain containing 10 FLJ20156 15q22.32 hypothetical protein FLJ20156 LOC283675 15q22.32 similar to ribosomal protein L5; 60S ribosomal protein L5 LOC196993 15q22.32 hypothetical protein LOC196993 LOC390602 15 similar to High mobility group protein 1 (HMG-1) (Amphoterin) (Heparin-binding protein p30) LOC196994 15q22.32 similar to hypothetical protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 5043 70 617 - Li (2001)
    EXPRESSION
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • D-glucuronyl C5-epimerase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • essential for heparin biosynthesis in mast cells (Feyerabend 2006)
  • key enzyme in proteoglycan biosynthesis (Grigorieva 2008)
  • involvement in malignant transformation (Grigorieva 2008)
  • enzyme responsible for the epimerization of D-glucuronic acid into L-iduronic acid of heparan sulphate, endows the nascent polysaccharide chain with the ability to bind to growth factors and cytokines (Ghiselli 2005)
  • conversion of d-glucuronic acid to l-iduronic acid units in heparan sulfate biosynthesis (Hagner-McWhirter 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by beta-catenin-TCF4 transactivation pathway that plays a major role in modulating GLCE expression, thus contributing to the regulation of Heparan sulfate biosynthesis and its structural organization (Ghiselli 2005)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer (Grigorieva 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    disruption of the Hsepi gene in mice yielded a lethal phenotype with selective organ defects but had remarkably little effect on other organ systems (Jia 2009)