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FLASH GENE
Symbol GKN2 contributors: - updated : 27-02-2007
HGNC name gastrokine 2
HGNC id 24588
Location 2p14      Physical location : 69.172.364 - 69.180.102
Synonym name
  • blottin
  • down regulated in gastric cancer GDDR
  • trefoil factor interactions(z) 1
  • Synonym symbol(s) GDDR, PRO813, TFIZ1, VLTI465
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivestomach    
    Respiratorylung    
    Visualeyeretinafovea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)  
    Epithelialsensoryvisualphotoreceptor layer 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivegastric
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    an approximately 100 amino acid BRICHOS domain
    HOMOLOGY
    intraspecies homolog to GKN1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION may play a role in gastrointestinal mucosal protection and modulate gut epithelial cell proliferation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimer comprises one molecule each of TFF1 and GKN2, and the disulfide bond between TFF1 and GKN2 is the most important factor stabilizing the heterodimer
    INTERACTION
    DNA
    RNA
    small molecule
    protein TFF1 protein partner
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS