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FLASH GENE
Symbol GKN1 contributors: mct - updated : 16-06-2020
HGNC name gastrokine 1
HGNC id 23217
Location 2p13.3      Physical location : 69.201.704 - 69.208.111
Synonym name
  • 18 kDa antrum mucosa protein
  • BRICHOS domain containing 1
  • Synonym symbol(s) AMP18, CA11, BRICD1, FOV, MGC70354, foveolin
    DNA
    TYPE functioning gene
    STRUCTURE 6.34 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 753 - 185 - 2019 31320708
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     stomach   predominantly Homo sapiens
    Reproductivefemale systemuterus  lowly
     female systemplacenta    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text lowly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • NH2-terminal hydrophobic region and BRICHOS domain that are sufficient for its tumor suppressor activities
  • secondary structure
  • presence of at least a disulphide bond between Cys61 and one of the other three Cys (Cys122, Cys145 and Cys159)
  • isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Gkn1
    ortholog to rattus gkn1
    Homologene
    FAMILY BRICHOS domain family
    CATEGORY secretory , tumor suppressor , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    text cosecreted with mucins
    basic FUNCTION
  • mitogenic activity
  • may be involved in maintaining the integrity of the gastric mucosal epithelium
  • inactivation of the GKN1 gene may play an important role in the development of sporadic gastric cancers, as an early event
  • GKN1 is a secreted protein with similar expression and biological functions to TFF1
  • GKN1, GKN2, secreted proteins that are products of gastric mucus-producing cell lineages
  • primary structure coupled to proteolytic experiments highlighted that GKN1 was essentially resistant to proteolytic enzymes
  • plays an important role in maintaining gastric mucosa integrity
  • plays a major role in maintaining gastric mucosa integrity
  • plays important roles in maintaining mucosal homeostasis, and in regulating cell proliferation and differentiation
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GKN2 may contribute to the homeostasis of gastric epithelial cells by inhibiting GKN1 activity
  • GKN1 inhibits cellinvasion by downregulating MMP2 expression through the NFKB1 pathway
  • UBR5 bound the tumor suppressor gastrokine 1 (GKN1) and increased its ubiquitination to reduce the protein stability of GKN1
  • GKN1 directly interacted with APP C-terminal fragments, C83 and C99
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significant reduction of GKN1 and GKN2 genes expression in the cancerous specimens in comparison with the normal tissues
    tumoral     --low  
    is tightly associated with gastric carcinogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum GKN1 is a promising and highly specific diagnostic biomarker for the prompt detection of early and advanced gastric cancers
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    GKN1-mediated inhibition of APP processing might represent a new approach for the prevention and therapy of Alzheimer disease (AD)
    cancerdigestivestomach
    GKN1 is a potential novel therapeutic target for gastric cancer
    ANIMAL & CELL MODELS