basic FUNCTION
| mitogenic activity |
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may be involved in maintaining the integrity of the gastric mucosal epithelium |
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inactivation of the GKN1 gene may play an important role in the development of sporadic gastric cancers, as an early event |
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GKN1 is a secreted protein with similar expression and biological functions to TFF1 |
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GKN1, GKN2, secreted proteins that are products of gastric mucus-producing cell lineages |
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primary structure coupled to proteolytic experiments highlighted that GKN1 was essentially resistant to proteolytic enzymes |
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plays an important role in maintaining gastric mucosa integrity |
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plays a major role in maintaining gastric mucosa integrity |
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plays important roles in maintaining mucosal homeostasis, and in regulating cell proliferation and differentiation |