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FLASH GENE
Symbol GK2 contributors: mct - updated : 04-01-2012
HGNC name glycerol kinase 2
HGNC id 4291
Location 4q21.21      Physical location : 80.327.507 - 80.329.372
Synonym name
  • glycerol kinase testis specific 2
  • glycerol kinase, pseudogene 2
  • Synonym symbol(s) GKL1, GKTA, GKP2, GALK2, BCP-77
    EC.number 2.7.1.30, 2.7.1.157
    DNA
    TYPE functioning gene
    STRUCTURE 1.87 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1899 60.5 553 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an approximately 40-AA F-box motif
  • HOMOLOGY
    interspecies ortholog to murine Gk-rs2
    Homologene
    FAMILY
  • GHMP kinase family
  • FGGY kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text
  • localized to the outer membrane of the mitochondrion
  • basic FUNCTION
  • being a key enzyme in the regulation of glycerol uptake and metabolism
  • functions to catalyze the ATP-dependent conversion of glycerol to glycerol 3-phosphate
  • via its catalytic activity, GK2 plays an essential role in the regulation of glycerol uptake and metabolism
  • involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through target proteins, such as cyclins, cyclin-dependent kinase inhibitors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycerol-3-phosphate metabolism
    a component SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS