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FLASH GENE
Symbol GK2 contributors: mct - updated : 04-01-2012
HGNC name glycerol kinase 2
HGNC id 4291
Location 4q21.21      Physical location : 80.327.507 - 80.329.372
Synonym name
  • glycerol kinase testis specific 2
  • glycerol kinase, pseudogene 2
  • Synonym symbol(s) GKL1, GKTA, GKP2, GALK2, BCP-77
    EC.number 2.7.1.30, 2.7.1.157
    DNA
    TYPE functioning gene
    STRUCTURE 1.87 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ART3 4p15.1-p14 ADP-ribosyltransferase 3 NUP54 4q21.1 nucleoporin 54kDa SCARB2 4q21.1 scavenger receptor class B, member 2 GENX-3414 4q24-q25 genethonin 1 FLJ25770 4q21.22 hypothetical protein FLJ25770 ShrmL 4q21.22 Shroom-related protein LOC152825 4q21.22 similar to ribosomal protein L26 LOC345079 4q21.22 similar to RIKEN cDNA 5730467H21 FLJ10849 4q21.22 hypothetical protein FLJ10849 AF357530 4q21.1 thioredoxin 1 pseudogene 3 CCNI 4pter-qter cyclin I LOC339966 4q21.22 similar to Gene product with similarity to Ubiquitin binding enzyme CCNG2 4q21.22 cyclin G2 CXCL13 4q21 chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) CNOT6L 4q13.3 CCR4-NOT transcription complex, subunit 6-like MRPL1 4q21.1 mitochondrial ribosomal protein L1 LOC391670 4 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) FRAS1 4q21.21 Fraser syndrome 1 ANXA3 4q13-q22 annexin A3 LOC391671 4 similar to ribosomal protein S21; 40S ribosomal protein S21 BMP2K 4q21.23 BMP2 inducible kinase PAQR3 4q21.23 progestin and adipoQ receptor family member III GK2 4q13 glycerol kinase 2 OR7E94P 4q27 olfactory receptor, family 7, subfamily E, member 94 pseudogene GDEP 4q21.1 olfactory receptor, family 7, subfamily E, member 94 pseudogene ANTXR2 4q21.3 anthrax toxin receptor 2 LOC339991 4q21.3 similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) PRDM8 4q21 PR domain containing 8 FGF5 4q21 fibroblast growth factor 5 MRPS25P1 4q21.23 mitochondrial ribosomal protein S25 pseudogene MGC35043 4q21.3 hypothetical protein MGC35043 BMP3 4p14-q21 bone morphogenetic protein 3 (osteogenic) PRKG2 4q13.1-q21.1 protein kinase, cGMP-dependent, type II GPIG4 COX5BL1 4cen-q31 cytochrome c oxidase subunit Vb-like 1 LOC345258 4q21.3 similar to bridging integrator 2; bridging integrator-2; breast cancer associated protein BRAP1 HNRPD 4q21.1-q21.2 heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) LOC391672 4 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) HNRPDL 4q13-q21 heterogeneous nuclear ribonucleoprotein D-like MASA 4q21.3 E-1 enzyme
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1899 60.5 553 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an approximately 40-AA F-box motif
  • HOMOLOGY
    interspecies ortholog to murine Gk-rs2
    Homologene
    FAMILY
  • GHMP kinase family
  • FGGY kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text
  • localized to the outer membrane of the mitochondrion
  • basic FUNCTION
  • being a key enzyme in the regulation of glycerol uptake and metabolism
  • functions to catalyze the ATP-dependent conversion of glycerol to glycerol 3-phosphate
  • via its catalytic activity, GK2 plays an essential role in the regulation of glycerol uptake and metabolism
  • involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through target proteins, such as cyclins, cyclin-dependent kinase inhibitors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycerol-3-phosphate metabolism
    a component SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS