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FLASH GENE

Symbol

GJC3

contributors: ktn/npt - updated : 05/01/2009

HGNC name	gap junction protein, gamma 3, 30.2kDa
HGNC id	17495

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q22.1      Physical location : 99.520.891 - 99.527.243
Synonym name	gap junction protein, epsilon 1, 29kDa
	connexin 29
	connexin 31.3
	connexin 30.2
Synonym symbol(s)	Cx29, GJE1, CX30.2, CX31.3

DNA

TYPE	functioning gene
STRUCTURE	6.08 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 2 - 840 isoform 1 31.2 279 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       highly   pancreas exocrine       moderately Nervous brain           nerve spinal nerve sciatic       spinal cord         Reproductive female system breast mammary gland   lowly Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly Nervous central       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

hexamer

HOMOLOGY

interspecies	homolog to rattus Gje1 (66.5 pc)
	homolog to murine Gje1 (66.2 pc)

Homologene

FAMILY	connexin family
	gamma-type subfamily

CATEGORY

regulatory , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane,junction,gap
text	myelin sheath
	multi-pass membrane protein

basic FUNCTION

participating in the formation of active channels when coexpressed with Cx32

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

cell to cell transport

text	materials of low molecular weight diffuse from one cell to a neighboring cell

PATHWAY

metabolism

signaling

a component

connexon composed of a hexamer of connexins

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS