SUBCELLULAR LOCALIZATION
| plasma membrane,junction,gap
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| basic FUNCTION
| oligomerizing to form intercellular channel that are clustered at gap junctions |
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playing a major role in homeostasis of the cortilymph through the epithelial cell system and in the function of the organ of Corti |
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maybe involved in cornified envelope formation |
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play a crucial role in inner ear Ca2+ signaling: as hemichannels, they promote ATP release, sustaining long-range intercellular Ca2+ signals propagation  |
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play an important role in lymphatic invasion as well as lymph node and distant metastases in squamous lung cancer and breast cancer |
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both GJB2 and GJB6 play essential roles in normal cochlear functions |
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plays an essential role in the postnatal development of the normal cochlear sensory epithelium, the organ of Corti |
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plays an essential role in the development of the auditory sensory epithelium and its unique developmental functions required for normal hearing is not replaceable by GJB6 |
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GJB2, and GJB6 have dramatically different temporal and cellular expression patterns during early postnatal cochlear development |
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GJB2- hemichannels may play a role in Ca(2+) influx into cells under conditions that lead to hemichannel activation, such as ischemic damage |
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appears to be essential for normal development of the auditory sensory epithelium, but may be dispensable during normal hearing |
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in the cochlea, GJB2, GJB6 largely co-assemble into heteromeric gap junctions, which connect adjacent non-sensory epithelial cells |
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presence of non-junctional GJB2/GJB6 oligomers within lipid raft-enriched tricellular junction sites |
