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FLASH GENE
Symbol GIPR contributors: mct - updated : 29-05-2012
HGNC name gastric inhibitory polypeptide receptor
HGNC id 4271
Location 19q13.32      Physical location : 46.171.501 - 46.185.717
Synonym name glucose-dependent insulinotropic polypeptide receptor
Synonym symbol(s) MGC126722, GIP-R, PGQTL2
DNA
TYPE functioning gene
STRUCTURE 14.22 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
motif repetitive sequence   ALU
text structure
  • including 17 Alu repeats
  • Sp transcription factor family
    • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text several splice variants (PMID: 12721154)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2024 - 466 - 1995 8575774
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestinelarge intestinecolon moderately
    Endocrinepancreasislet of Langerhans  predominantly Homo sapiens
    Nervousbrain   moderately
    Respiratorylung   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    Nervousoligodendrocyte
    NervousSchawnn cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal part crucial for biological activity
  • AAs involved in functional interaction with N-terminal moiety of GIP
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Gipr
    ortholog to murine Gipr
    Homologene
    FAMILY
  • family B of the G-protein coupled receptors
  • G-protein coupled receptor 2 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to plasma membrane
    basic FUNCTION
  • acting as a gastric inhibitory polypeptide receptor
  • may play a critical role in adipocyte development
  • might represent a gene expressed early in terminal differentiation and thus plays a role in fat droplet formation
  • putative modulatory functions of GIP/GIPR signaling in adult neurons
  • critical role of GIP/GIPR signal transduction in promoting spontaneous recovery after nerve crush
  • implication of GIPR in insulin secretion
  • role in the incretin effect and in early pathophysiologic pathways that could lead to impaired glucose tolerance and T2D
  • GLP1R, GIPR, and GCGR internalize with differential properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    activity of this receptor is mediated by G proteins which
    activate adenylyl cyclase
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cross-talk between the two incretin receptors GLP1R and GIPR is shown to alter receptor trafficking with functional consequences for GLP1R signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to obesity
    Variant & Polymorphism other variants associated to obesity
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    might represent a suitable target for the treatment of obesity
    ANIMAL & CELL MODELS