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FLASH GENE
Symbol GIPR contributors: mct - updated : 29-05-2012
HGNC name gastric inhibitory polypeptide receptor
HGNC id 4271
Location 19q13.32      Physical location : 46.171.501 - 46.185.717
Synonym name glucose-dependent insulinotropic polypeptide receptor
Synonym symbol(s) MGC126722, GIP-R, PGQTL2
DNA
TYPE functioning gene
STRUCTURE 14.22 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
motif repetitive sequence   ALU
text structure
  • including 17 Alu repeats
  • Sp transcription factor family
  • MAPPING cloned Y linked N status confirmed
    Physical map
    MGC2650 19q13.32 hypothetical protein MGC2650 LOC388552 19 similar to BC043666 protein XTP7 19q13.32 protein 7 transactivated by hepatitis B virus X antigen (HBxAg) MARK4 19q13.2 MAP/microtubule affinity-regulating kinase 4 CKM 19q13.2 creatine kinase, muscle LOC390943 19 similar to 40S ribosomal protein S16 KLC2L 19q13.3 similar to 40S ribosomal protein S16 ERCC2 19q13.3 excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D) RAI 19q13.32 RelA-associated inhibitor ASE-1 19q13.3 RelA-associated inhibitor ERCC1 19q13.3 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) FOSB 19q13.3 FBJ murine osteosarcoma viral oncogene homolog B RTN2 19q13.3 reticulon 2 VASP 19q13.2-q13.3 vasodilator-stimulated phosphoprotein FLJ40125 19q13.32 hypothetical protein FLJ40125 OPA3 19q13.32 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) GPR4 19q13.3 G protein-coupled receptor 4 EML2 19q13.32 echinoderm microtubule associated protein like 2 GIPR 19q13.3 gastric inhibitory polypeptide receptor SNRPD2 19q13.2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa FLJ20084 19q13.32 hypothetical protein FLJ20084 20D7-FC4 LOC388553 19 LOC388553 SIX5 19q13.3 sine oculis homeobox homolog 5 (Drosophila) DMPK 19q13.3 dystrophia myotonica-protein kinase DMWD 19q13.3 dystrophia myotonica-containing WD repeat motif RSHL1 19q13.3 radial spokehead-like 1 SYMPK 19q13.32 symplekin FOXA3 19q13.2-q13.4 forkhead box A3 IRF2BP1 19q13.32 interferon regulatory factor 2 binding protein 1 LOC339344 19q13.32 hypothetical protein LOC339344 NANOS2 19q13.32 nanos homolog 2 (Drosophila) NOVA2 19q13.3 neuro-oncological ventral antigen 2 LOC388554 19 similar to BC282485_1 PGLYRP 19q13.2-q13.3 peptidoglycan recognition protein
    RNA
    TRANSCRIPTS type messenger
    text several splice variants (PMID: 12721154)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2024 - 466 - 1995 8575774
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestinelarge intestinecolon moderately
    Endocrinepancreasislet of Langerhans  predominantly Homo sapiens
    Nervousbrain   moderately
    Respiratorylung   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    Nervousoligodendrocyte
    NervousSchawnn cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal part crucial for biological activity
  • AAs involved in functional interaction with N-terminal moiety of GIP
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Gipr
    ortholog to murine Gipr
    Homologene
    FAMILY
  • family B of the G-protein coupled receptors
  • G-protein coupled receptor 2 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to plasma membrane
    basic FUNCTION
  • acting as a gastric inhibitory polypeptide receptor
  • may play a critical role in adipocyte development
  • might represent a gene expressed early in terminal differentiation and thus plays a role in fat droplet formation
  • putative modulatory functions of GIP/GIPR signaling in adult neurons
  • critical role of GIP/GIPR signal transduction in promoting spontaneous recovery after nerve crush
  • implication of GIPR in insulin secretion
  • role in the incretin effect and in early pathophysiologic pathways that could lead to impaired glucose tolerance and T2D
  • GLP1R, GIPR, and GCGR internalize with differential properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    activity of this receptor is mediated by G proteins which
    activate adenylyl cyclase
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cross-talk between the two incretin receptors GLP1R and GIPR is shown to alter receptor trafficking with functional consequences for GLP1R signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to obesity
    Variant & Polymorphism other variants associated to obesity
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    might represent a suitable target for the treatment of obesity
    ANIMAL & CELL MODELS