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FLASH GENE
Symbol GIPC2 contributors: mct - updated : 24-08-2010
HGNC name GIPC PDZ domain containing family, member 2
HGNC id 18177
Location 1p31.1      Physical location : 78.511.588 - 78.603.111
Synonym name
  • likely ortholog of mouse
  • semaF cytoplasmic domain associated protein 2
  • PDZ domain protein GIPC2
  • Synonym symbol(s) SEMCAP2, FLJ20075, SEMCAP-2
    DNA
    TYPE functioning gene
    STRUCTURE 91.52 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DKFZp547I048 1p31.1 hypothetical protein DKFZp547I048 CRYZ 1p31-p22 crystallin, zeta (quinone reductase) LOC388640 1 similar to crystallin, zeta; NADPH:quinone reductase LOC127253 1p31.1 hypothetical protein BC009514 LOC148864 1p31.1 similar to LIM homeo domain transcription factor MGC34032 1p31.1 hypothetical protein MGC34032 LOC388641 1 LOC388641 LOC343221 1p31.1 similar to KIAA0433 protein ACADM 1p31 acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain DLSTP 1p31 dihydrolipoamide S-succinyltransferase pseudogene (E2 component of 2-oxo-glutarate complex) RABGGTB 1p31 Rab geranylgeranyltransferase, beta subunit MSH4 1p31 mutS homolog 4 (E. coli) ASB17 1p31.1 ankyrin repeat and SOCS box-containing 17 SIAT7C 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C LOC388642 1 similar to Triosephosphate isomerase (TIM) LOC388643 1 LOC388643 SIAT7E 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E LOC256483 1p31.1 hypothetical LOC256483 PIGK 1p31.1 phosphatidylinositol glycan, class K AK5 1p31 adenylate kinase 5 DKFZP564I052 USP33 1p31.1 ubiquitin specific protease 33 FLJ35093 1p31.1 FLJ35093 protein LOC91624 FUBP1 1p31.1 far upstream element (FUSE) binding protein 1 DNAJB4 1p31.1 DnaJ (Hsp40) homolog, subfamily B, member 4 LOC339425 1p31.1 similar to Nit protein 2 GIPC2 1p31.1 PDZ domain protein GIPC2 LOC388644 1 hypothetical gene supported by AK091757 PTGFR 1p31.1 prostaglandin F receptor (FP) C1orf29 1p31.1 chromosome 1 open reading frame 29 IFI44 1p31.1 interferon-induced protein 44 LOC343295 1p31.1 similar to Nuclear protein SkiP (Ski-interacting protein) (SNW1 protein) (Nuclear receptor coactivator NCoA-62) ELTD1 1p33-p32 EGF, latrophilin and seven transmembrane domain containing 1 LOC149050 1p31.1 similar to phosphoserine aminotransferase isoform 1 LOC343296 1p31.1 similar to Alcohol dehydrogenase class III chi chain (Glutathione-dependent formaldehyde dehydrogenase) (FDH) LOC391049 1 similar to Rda288-prov protein COX6A1P 1p31.1 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene LOC391050 1 similar to ribosomal protein L7 LOC343301 1p31.1 similar to ribosomal protein L10a
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2838 34.4 315 - Kirikoshi (2002)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver    
    Endocrineadrenal gland    
     pancreas    
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarybladder    
     kidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a central PDZ domain, which interact with Frizzled-3 (FZD3) class of WNT receptor, insulin-like growth factor-I (IGF1) receptor, receptor tyrosine kinase TrkA, TGF-beta type III receptor (TGF-beta RIII), integrin alpha6A subunit, transmembrane glycoprotein 5T4, and RGS19/RGS-GAIP (Katoh 2002)
  • GIPC homology (GH1 and GH2) domains
  • HOMOLOGY
    interspecies ortholog to murine Gipc2
    intraspecies paralog to GIPC1
    Homologene
    FAMILY
  • GIPC family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • might play important roles in human gastric cancer through modulation of growth factor signaling or cell adhesion (Kirikoshi 2002)
  • may be involved in intracellular signaling cascade
  • might play key roles in carcinogenesis and embryogenesis through modulation of growth factor signaling and cell adhesion (Katoh 2002)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind TGFBR3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in colon, kidney, and rectal tumor
    tumoral     --over  
    in gastric cancer
    tumoral     --other  
    aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS