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FLASH GENE
Symbol GINS4 contributors: mct - updated : 25-08-2016
HGNC name GINS complex subunit 4 (Sld5 homolog)
HGNC id 28226
Location 8p11.21      Physical location : 41.386.724 - 41.402.563
Genatlas name Go, Ichi, Nii, and San (GINS)complex subunit 4 (Psf4 homolog)
Synonym name
  • synthetic lethality with Dpb11
  • Synonym symbol(s) SLD5
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     8 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • an N-terminal coiled-coil domain
  • a central basic region
  • two types of structural domains: an alpha -helix rich (A) domain and a beta-strand rich (B) domain
  • a C-terminal domain conserved between the mouse and yeast proteins
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Gins4 (87.9 pc)
    intraspecies paralog to GINS1
    paralog to GINS2
    paralog to GINS3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • playing an essential role in the initiation and elongation phases of genome duplication
  • GINS complex is a key factor for establishing the initiation complex after prereplicative complex assembly and important for the normal progression of the replisome
  • replication complex that in S phase, associates first with replication origins and then with neighboring sequences (Takayama 2003)
  • essential for initiation of DNA replication and S phase progression and directly involved in cellular processes
  • necessary for proliferation and viability (Aparicio 2009)
    CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer composed of GINS1, GINS2, GINS3, GINS4
  • part of the the GINS complex, an integral component of the replicative helicase machinery that facilitates progression of the replisome complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting directly with the heterodimeric human DNA primase
  • interacts with DNA replication factors MCM and CDC45 in chromatin during S phase (Aparicio 2009)
  • GINS1, GINS2, GINS3, GINS4 and TICRR compete with one another for MCM2-7 and CDC45 binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS