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FLASH GENE
Symbol GINS3 contributors: SGE/npt - updated : 25-08-2016
HGNC name GINS complex subunit 3 (Psf3 homolog)
HGNC id 25851
Location 16q21      Physical location : 58.426.297 - 58.440.047
Synonym name
  • partner of Sld5 3
  • Go, Ichi, Nii, and San (GINS)complex subunit 3 (Psf3 homolog)
  • Synonym symbol(s) PSF3, FLJ13912
    DNA
    TYPE functioning gene
    STRUCTURE 13.75 kb     4 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2414 - 255 - -
  • isoform a
  • 3 - 2297 - 216 - -
  • isoform b
  • 2 - 2063 - 138 - -
  • isoform c
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Endocrineadrenal gland   highly
    Lymphoid/Immunelymph node   moderately
    Nervousbrain   moderately
     nerve   highly
    Reproductivefemale systembreastmammary gland moderately
     female systemuteruscervix highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    physiological period fetal
    Text predominantly in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two types of structural domains: an alpha-helix rich (A) domain and a beta-strand rich (B) domain
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Gins3 (89.4 pc)
    homolog to rattus Gins3 (90.3pc)
    intraspecies paralog to GINS1
    paralog to GINS2
    paralog to GINS4
    Homologene
    FAMILY
  • GINS3/PSF3 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as a gene responsive to transcription factor E2F1
  • playing an essential role in the initiation and elongation phases of genome duplication
  • GINS complex is a key factor for establishing the initiation complex after prereplicative complex assembly and important for the normal progression of the replisome
  • replication complex that in S phase, associates first with replication origins and then with neighboring sequences (Takayama 2003)
  • essential for initiation of DNA replication and S phase progression and directly involved in cellular processes
  • necessary for proliferation and viability (Aparicio 2009)
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer composed of GINS1, GINS2, GINS3, GINS4
  • part of the the GINS complex, an integral component of the replicative helicase machinery that facilitates progression of the replisome complex
  • forming a stable subcomplex with GINS2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting directly with the heterodimeric human DNA primase
  • interacts with DNA replication factors MCM and CDC45 in chromatin during S phase (Aparicio 2009)
  • GINS1, GINS2, GINS3, GINS4 and TICRR compete with one another for MCM2-7 and CDC45 binding
  • cell & other
    REGULATION
    induced by serum stimulation
    Other expression regulated by 17beta-Estradiol-stimulated estrogen receptor alpha
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    expression is greater in colon carcinoma compared with the adjacent normal mucosa (Nagahama 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • may be associated with colon cancer progression (Nagahama 2010)
  • Marker
    Therapy target
  • potential biomarker for diagnosis of progression in colon cancer and could be a new target for cancer therapy (Nagahama 2010)
  • ANIMAL & CELL MODELS