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FLASH GENE
Symbol GINS2 contributors: mct/npt - updated : 25-08-2016
HGNC name GINS complex subunit 2 (Psf2 homolog)
HGNC id 24575
Location 16q24.1      Physical location : 85.711.280 - 85.722.588
Synonym name
  • DNA replication complex GINS protein PSF2
  • partner of Sld five 1
  • Go, Ichi, Nii, and San (GINS)complex subunit 2 (Psf2 homolog)
  • Synonym symbol(s) HSPC037, PSF2, Pfs2
    DNA
    TYPE functioning gene
    STRUCTURE 11.30 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1196 - 185 - Takayama (2003)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two types of structural domains: an alpha -helix rich (A) domain
  • a beta-strand rich (B) domain
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • GINS2/PSF2 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in DNA replication
  • having an essential role in the initiation and elongation phases of genome duplication
  • GINS complex is a key factor for establishing the initiation complex after prereplicative complex assembly and important for the normal progression of the replisome
  • replication complex that in S phase, associates first with replication origins and then with neighboring sequences (Takayama 2003)
  • essential for initiation of DNA replication and S phase progression and directly involved in cellular processes
  • necessary for proliferation and viability (Aparicio 2009)
  • involved in replication initiation and elongation, and is known to play a role in ICL repair
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the GINS complex which is a heterotetramer of SLD5, GINS1, GINS2 and PSF3
  • part of the the GINS complex, an integral component of the replicative helicase machinery that facilitates progression of the replisome complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact directly with the heterodimeric DNA primase
  • interacts with DNA replication factors MCM and CDC45 in chromatin during S phase (Aparicio 2009)
  • GINS1, GINS2, GINS3, GINS4 and TICRR compete with one another for MCM2-7 and CDC45 binding
  • DCLRE1B bind GINS2 in human cells through two regions, strongly to a 144 amino acid N-terminal region and weakly to a second smaller 37 amino acid C-terminal region
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS