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FLASH GENE
Symbol GIMAP8 contributors: mct - updated : 30-04-2011
HGNC name GTPase, IMAP family member 8
HGNC id 21792
Location 7q36.1      Physical location : 150.147.961 - 150.176.482
Synonym name
  • immune associated nucleotide
  • human immune associated nucleotide 6
    • Synonym symbol(s) hIAN6, DKFZp667I133, IAN-9, IAN6, IANT, MGC129545
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 28.52 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3952 - 665 - 2002 11814688
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Nervousgangliasensory gangliadorsal root  
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE)  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three consecutive GIMAP-specific G domains
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • potentially exerting an anti-apoptotic effect in the immune system and is involved in responses to infections
  • might contribute to the pathogenesis of and immune reactions to non-small cell lung cancer
  • role for GIMAPs in the late stages of lymphocyte development and in lymphocyte maintenance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS