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FLASH GENE
Symbol GIMAP6 contributors: mct - updated : 24-03-2016
HGNC name GTPase, IMAP family member 6
HGNC id 21918
Location 7q36.1      Physical location : 150.322.465 - 150.329.680
Synonym name
  • human immune associated nucleotide 2
  • immune associated nucleotide 6
  • Synonym symbol(s) FLJ22690, IAN6, FLJ00102, hIAN2, IAN-2, IAN-6
    DNA
    TYPE functioning gene
    STRUCTURE 7.27 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3716 32 292 - 2004 15474311
    isoform 1
    3 - 3492 - 62 - 2004 15474311
  • using a downstream start codon that results in a shorter protein (isoform 3) with a distinct N-terminus
  • also using an alternate splice site in the 3' coding region that restores the reading frame so that the C-terminus of isoform 3 is identical to that of isoform 1
  • 3 - 3926 - 362 - 2004 15474311
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Endocrineadrenal gland    
     parathyroid    
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivefemale systemplacenta   
    Respiratoryrespiratory tracttrachea   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region of GIMAP6, which includes a putative GABARAPL2-family interacting motif, not required or interacting with GABARAPL2
  • HOMOLOGY
    Homologene
    FAMILY
  • GTP-binding superfamily
  • immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • role for GIMAPs in the late stages of lymphocyte development and in lymphocyte maintenance
  • likely play roles in the regulation of autophagy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • interaction between the human cytosolic family member GIMAP6 and GABARAPL2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS