Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GIMAP5 contributors: mct - updated : 04-05-2011
HGNC name GTPase, IMAP family member 5
HGNC id 18005
Location 7q36.1      Physical location : 150.434.450 - 150.440.736
Genatlas name GTPase of immunity-associated nucleotide binding protein 5
Synonym name
  • immuno-associated nucleotide binding protein 4
  • immunity associated protein 3
  • immune associated nucleotide 4 like 1 (mouse)
  • Synonym symbol(s) IAN4, HIMAP3, IAN4L1, IAN5, FLJ11296
    DNA
    TYPE anonymous DNA segment
    SPECIAL FEATURE component of a cluster
    STRUCTURE 6.29 kb     3 Exon(s)
    motif repetitive sequence   other
    text structure two consecutive polyA signals and one SNP
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1861 - 307 - 2007 17369194
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineadrenal gland   highly
    Lymphoid/Immunespleen   highly
    Respiratorylung    
    cell lineage hemapoietic cells, predominantly
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal GTP binding motif
  • central coiled-coil domain responsible for centrosomal anchoring and resistance toward death
  • five motifs conserved in GTP-binding proteins
  • one hydrophobic segments at the C terminus predicted to form transmembrane (TM) spanning helices
  • HOMOLOGY
    interspecies homolog to murine Ian4
    ortholog to murine Imap38
    Homologene
    FAMILY immune-associated nucleotide (Ian)-related gene family
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text
  • localization at the endoplasmic reticulum
  • found to be located in a membraneous compartment/s which was also detected by established markers of lysosomes
  • basic FUNCTION
  • putative GTP-binding activity, may be playing a role in the control of cell death/survival
  • regulates T lymphocyte survival by mechanisms that operate upstream of mitochondria
  • important regulator of calcium response in T lymphocytes
  • role for GIMAPs in the late stages of lymphocyte development and in lymphocyte maintenance
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with members of the BCL2 family and regulate apoptosis
  • CISD2 interact with GIMAP5 on the mitochondrial and ER membranes and thereby modulate mitochondrial Ca(2+) uptake associated with the maintenance of intracellular Ca(2+) homeostasis in adipocytes
  • cell & other
    REGULATION
    activated by by NOTCH1 in T-ALL cell lines (NOTCH1 signalling protects T-ALL cells from apoptosis by upregulating the expression of GIMAP5)
    induced by BCR/ABL
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    resulted in a major increase in the number of apoptotic cells
    Susceptibility to systemic lupus erythematosus
    Variant & Polymorphism repeat common polyadenylation polymorphism increasing risk to systemic lupus erythematosus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS