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FLASH GENE
Symbol GIMAP2 contributors: mct - updated : 30-04-2011
HGNC name GTPase, IMAP family member 2
HGNC id 21789
Location 7q36.1      Physical location : 150.382.793 - 150.390.726
Synonym name immunity associated protein 2
Synonym symbol(s) IMAP2, MGC24275, HIMAP2, MGC24275, DKFZp586D0824
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text seven GIMAP genes are clustered on chromosome 7
STRUCTURE 7.94 kb     3 Exon(s)
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1523 38 337 - 2002 11814688
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal G domain containing a GIMAP-specific signature motif
  • the conserved box
  • distinct C-terminal extensions of 60130 AAs length
  • one or two additional hydrophobic segments at the C terminus predicted to form transmembrane (TM) spanning helices
  • mono polymer monomer , oligo
    HOMOLOGY
    Homologene
    FAMILY
  • immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins
  • GIMAP family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • resides mainly at the phospholipid monolayer surrounding the lipid droplet core of neutral lipids
  • basic FUNCTION
  • involved in the control of cell survival not only in cells of the immune system as commonly anticipated
  • important regulators of T-cell death and survival (
  • role for GIMAPs in the late stages of lymphocyte development and in lymphocyte maintenance
  • control apoptosis in lymphocytes and play a central role in lymphocyte maturation and lymphocyte-associated diseases
  • function for the GIMAP2 oligomer at the surface of lipid droplets (LD), might act as a scaffold to assemble interaction partners on the LD membrane
  • CELLULAR PROCESS cell cycle
    cell life
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS