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FLASH GENE

Symbol

GHSR

contributors: mlc/npt - updated : 25-06-2017

HGNC name	growth hormone secretagogue receptor
HGNC id	4267

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	GHIS4 growth hormone insensitivity 4, partial
Location	3q26.31      Physical location : 172.161.080 - 172.166.246
Synonym name	growth hormone secretagogue receptor, type 1A
	ghrelin receptor
	GH-releasing peptide receptor
Synonym symbol(s)	GSHR1A, GHRP, GHS-R

DNA

TYPE	functioning gene
STRUCTURE	5.17 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Binding site   HRE
text structure	thyroid and estrogen responsive element glucocorticoid responsive element

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_198407 2 - 3014 41.3 366 . prostate carcinoma cells . is localized in the vicinity of hippocampal excitatory synapses 2010 21040709 GHSR1A 7 TM domains its activation in the hippocampus enhances excitatory synaptic transmission and synaptic plasticity by regulating AMPAR trafficking NM_004122 1 - 914 - 289 - 2010 21040709 GHSR1B with only five transmembrane domains which function is not yet known

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly Homo sapiens   pancreas       highly Homo sapiens   thyroid       highly Homo sapiens Nervous brain diencephalon hypothalamus     Homo sapiens   brain hindbrain cerebellum   highly Homo sapiens Reproductive male system prostate       Homo sapiens   male system testis     highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptors

HOMOLOGY

interspecies

homolog to C.elegans C53d5.5

Homologene

FAMILY

G protein coupled receptor family

CATEGORY

signaling hormone , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in the pulsatile hormone release control
	its high constitutive signaling activity is important for the function in the control of food intake and body weight
	is an important regulator of energy and glucose homeostasis and a target for the treatment of obesity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein	GHSR-mediated inhibition of CACNA1A, CACNA1B attenuates GABA release in hypothalamic neurons, a mechanism that could contribute to neuronal activation through the disinhibition of postsynaptic neurons
	LEAP2 fully inhibits GHSR activation by ghrelin and blocks the major effects of ghrelin, including food intake, GH release, and maintenance of viable glucose levels during chronic caloric restriction
	MRAP2 altered GHSR signaling by inhibiting its constitutive activity, as well as by enhancing its G protein-dependent signaling and blocking the recruitment and signaling of ARRB in response to ghrelin

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GHIS4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function in familial short stature ( constitutional     --over   in heart failure constitutional     --low   in endometrium from women with unexplained infertility may in part explain the infertility

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS