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FLASH GENE
Symbol GHRHR contributors: mct/ - updated : 24-08-2007
HGNC name growth hormone releasing hormone receptor
HGNC id 4266
Corresponding disease
GHRHR dwarfism with growth hormone deficiency
Location 7p14.3      Physical location : 31.003.635 - 31.019.146
Synonym name
  • GRF receptor
  • growth hormone-releasing hormone receptor form c
  • growth hormone-releasing hormone receptor form a
  • growth hormone-releasing hormone receptor form b
  • Synonym symbol(s) GHRFR, GHRHRpsv, GRFR, IGHD1B, GHRHRpsv
    DNA
    TYPE functioning gene
    STRUCTURE 15.51 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    DKFZp586I1420 7p15.1 hypothetical protein DKFZp586I1420 FAPP2 7p21-p11.2 phosphoinositol 4-phosphate adaptor protein-2 CARD4 7p15-p14 caspase recruitment domain family, member 4 Ells1 7p15.1 hypothetical protein Ells1 C7orf24 7p15-p14 chromosome 7 open reading frame 24 LOC392791 7 LOC392791 LOC392792 7 hypothetical gene supported by AK125651; BC039420 GARS 7p15 glycyl-tRNA synthetase LOC223082 7p15.1 zinc finger/RING finger 2 CRHR2 7p21-p15 corticotropin releasing hormone receptor 2 DKFZp586I1420 7p15.1 hypothetical protein DKFZp586I1420 INMT 7p15.3-p15.2 indolethylamine N-methyltransferase LOC392651 7 similar to hypothetical protein FLJ22374 CARD4 7p15-p14 caspase recruitment domain family, member 4 C7orf24 7p15-p14 chromosome 7 open reading frame 24 LOC392987 7 similar to ribosomal protein L27 AQP1 7p14 aquaporin 1 (channel-forming integral protein, 28kDa) GARS 7p15 glycyl-tRNA synthetase MKLN1 7q32 muskelin 1, intracellular mediator containing kelch motifs GHRHR 7p14 growth hormone releasing hormone receptor CRHR2 7p21-p15 corticotropin releasing hormone receptor 2 ADCYAP1R1 7p14 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I INMT 7p15.3-p15.2 indolethylamine N-methyltransferase FLJ22374 7p15.1 hypothetical protein FLJ22374 PODXL 7q32-q33 podocalyxin-like AQP1 7p14 aquaporin 1 (channel-forming integral protein, 28kDa) LOC392793 7 similar to eukaryotic translation elongation factor 1 beta 2; eukaryotic translation elongation factor 1 beta 1 LOC392988 7 similar to ribosomal protein S14 GHRHR 7p14 growth hormone releasing hormone receptor NEUROD6 7p15.3 neurogenic differentiation 6 ADCYAP1R1 7p14 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I LOC223075 7p15.1 hypothetical protein LOC223075 NEUROD6 7p15.3 neurogenic differentiation 6 C7orf16 7p15 chromosome 7 open reading frame 16 PLXNA4 7q32.3 plexin A4 PDE1C 7p15.3 phosphodiesterase 1C, calmodulin-dependent 70kDa LOC223075 7p15.1 hypothetical protein LOC223075 C7orf16 7p15 chromosome 7 open reading frame 16 DKFZp434G0625 7q32.3 hypothetical protein DKFZp434G0625 PDE1C 7p15.3 phosphodiesterase 1C, calmodulin-dependent 70kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1641 - 359 ubiquitous, normal and tumoral tissues Rekasi (2000)
  • also called SV1
  • 5' region from intron 3, (exon1, 2, 3 missing)
  • - - 1487 - 145 pituitary, not expressed in pancreas Rekasi (2000)
  • also called SV2
  • encode a GHRHR isoform truncated after the second transmembrane domain
  • - - 1311 - 151 normal prostate Rekasi (2000)
    also called SV3
    - - 1256 - 68 pituitary adenoma Rekasi (2000)
    also called SV4
    13 - 1617 47.3 423 - Pereira (2007)
    - - - - - - McElvaine (2006)
  • also called SV5
  • protein truncated just before the sixth transmembrane domain
  • acts as a dominant inhibitor of wild-type receptor signaling
  • wild-type and truncated GHRH receptor proteins form a complex
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  specific
    Respiratoryrespiratory tracttrachea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines pituitary adenoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • mono polymer heptamer
    HOMOLOGY
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • secretin family, coupling with Gs alpha protein and activating adenylate cyclase
  • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localizes to the surface of somatotroph cells and binds GHRH
    basic FUNCTION
  • stimulating somatotroph cell growth, growth hormone gene transcription and growth hormone secretion
  • can form multimers, which may be important to its signaling properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds GHRH
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GHRHR
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS