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FLASH GENE
Symbol GGN contributors: mct - updated : 12-01-2009
HGNC name gametogenetin
HGNC id 18869
Location 19q13.2      Physical location : 38.874.991 - 38.878.668
Synonym symbol(s) FLJ35713, MGC33369, GGN1
DNA
TYPE functioning gene
STRUCTURE 3.68 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2168 66.6 652 - 2003 12574169
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovaryovarian follicle   Homo sapiens
 male systemtestis  specific
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegranulosa cell Homo sapiens
Reproductivespermatid Homo sapiens
Reproductivespermatocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Ggn (74.9 pc)
homolog to murine Ggn (75.3 pc)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleolus
intracellular,nuclear envelope
text during mid-prophase, redistributes from a solely cytoplasmic localization to both cytoplasmic and nuclear in late prophase spermatocytes and round spermatids, and ultimately incorporated into the sperm tail
basic FUNCTION
  • regulating the localization of FANCL
  • playing a role in spermatogenesis
  • potential role for the GGN-CRISP2 complex in sperm tail development and/or motility
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FANCL, GGNBP1 and ZNF403/GGNBP2
  • interacting with CRISP2, between the ion channel regulatory region within the CRISP2 CRISP domain and the carboxyl-most 158 AAs of GGN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS