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FLASH GENE
Symbol GGN contributors: mct - updated : 12-01-2009
HGNC name gametogenetin
HGNC id 18869
Location 19q13.2      Physical location : 38.874.991 - 38.878.668
Synonym symbol(s) FLJ35713, MGC33369, GGN1
DNA
TYPE functioning gene
STRUCTURE 3.68 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC388537 19 hypothetical gene supported by NM_014761 LOC147975 19q13.13 hypothetical LOC147975 NYD-SP11 19q13.13 NYD-SP11 protein SIPA1L3 19q13.13 signal-induced proliferation-associated 1 like 3 DPF1 19q13.13 D4, zinc and double PHD fingers family 1 PPP1R14A 19q13.13-q13.2 protein phosphatase 1, regulatory (inhibitor) subunit 14A SPINT2 19q13.1 serine protease inhibitor, Kunitz type, 2 IMUP 19q13.13 serine protease inhibitor, Kunitz type, 2 LOC90522 19q13.13 similar to putative transmembrane protein; homolog of yeast Golgi membrane protein Yif1p (Yip1p-interacting factor) KCNK6 19q13.1 potassium channel, subfamily K, member 6 DKFZP434A1022 PSMD8 19q13.13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 GGN 19q13.13 gametogenetin LOC388538 19 similar to SPRED-3 LOC147965 19q13.2 hypothetical protein LOC147965 RASGRP4 19q13.1 RAS guanyl releasing protein 4 RYR1 19q13.1 ryanodine receptor 1 (skeletal) MAP4K1 19q13.2 mitogen-activated protein kinase kinase kinase kinase 1 eIF3k 19q13.2 mitogen-activated protein kinase kinase kinase kinase 1 ACTN4 19q13 actinin, alpha 4 CAPN12 19q13.2 calpain 12 LGALS7 19q13.2 lectin, galactoside-binding, soluble, 7 (galectin 7) LGALS4 19q13.2 lectin, galactoside-binding, soluble, 4 (galectin 4) ECH1 19q13.1 enoyl Coenzyme A hydratase 1, peroxisomal HNRPL 19q13.2 heterogeneous nuclear ribonucleoprotein L
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2168 66.6 652 - 2003 12574169
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovaryovarian follicle   Homo sapiens
 male systemtestis  specific
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegranulosa cell Homo sapiens
Reproductivespermatid Homo sapiens
Reproductivespermatocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Ggn (74.9 pc)
homolog to murine Ggn (75.3 pc)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleolus
intracellular,nuclear envelope
text during mid-prophase, redistributes from a solely cytoplasmic localization to both cytoplasmic and nuclear in late prophase spermatocytes and round spermatids, and ultimately incorporated into the sperm tail
basic FUNCTION
  • regulating the localization of FANCL
  • playing a role in spermatogenesis
  • potential role for the GGN-CRISP2 complex in sperm tail development and/or motility
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FANCL, GGNBP1 and ZNF403/GGNBP2
  • interacting with CRISP2, between the ion channel regulatory region within the CRISP2 CRISP domain and the carboxyl-most 158 AAs of GGN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS