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FLASH GENE
Symbol GGA2 contributors: mct/npt - updated : 19-04-2010
HGNC name golgi associated, gamma adaptin ear containing, ARF binding protein 2
HGNC id 16064
Location 16p12.2      Physical location : 23.474.863 - 23.521.815
Synonym name
  • ADP-ribosylation factor binding protein 2
  • VHS domain and ear domain of gamma-adaptin
  • gamma-adaptin-related protein 2
  • Golgi-localized, gamma ear-containing, ARF-binding protein 2
  • Synonym symbol(s) VEAR, KIAA1080, FLJ20966
    DNA
    TYPE functioning gene
    STRUCTURE 46.17 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   ALU   long interspersed repetitive elements
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC94431 16p12.3 similar to RNA polymerase I transcription factor RRN3 LOC390681 16 similar to RNA polymerase I transcription factor RRN3 MGC9515 16p12.3 hypothetical protein MGC9515 LOC390682 16 similar to PI-3-kinase-related kinase SMG-1 isoform 1; lambda/iota protein kinase C-interacting protein; phosphatidylinositol 3-kinase-related protein kinase LOC342293 16p12.3 similar to hypothetical protein UQCRC2 16p12.2 ubiquinol-cytochrome c reductase core protein II MGC50721 16p12.3 hypothetical protein MGC50721 LOC146174 16p12.3 hypothetical protein LOC146174 LOC146177 16p12.3 hypothetical protein LOC146177 LOC390683 16 similar to NAD(P) dependent steroid dehydrogenase-like EEF2K 16p12.1-q12.2 similar to NAD(P) dependent steroid dehydrogenase-like RPC5 16p12.3 RNA polymerase III 80 kDa subunit RPC5 CDR2 16p12.2 cerebellar degeneration-related protein 2, 62kDa LOC390684 16 similar to RRN3 LOC283846 16p12.3 PI-3-kinase-related kinase SMG-1-like LOC388225 16 similar to MGC9515 protein HS3ST2 16p12 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 KIAA1203 16p12.3 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 SCNN1G 16p12.2-p12.1 sodium channel, nonvoltage-gated 1, gamma SCNN1B 16p12.2-p12.1 sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) COG7 16p11.2 component of oligomeric golgi complex 7 GGA2 16p12 golgi associated, gamma adaptin ear containing, ARF binding protein 2 UBPH 16p12 similar to ubiquitin binding protein NDUFAB1 16p12.3-p12.1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa FLJ21816 16p12.3 hypothetical protein FLJ21816 MGC3248 16p12.3 dynactin 4 PLK LOC388226 16 similar to protein kinase/ribonuclease IRE1 beta ERN2 16p12.2 ER to nucleus signalling 2 LOC63928 16p12.3 hepatocellular carcinoma antigen gene 520 PRKCB1 16p12.1 protein kinase C, beta 1 CACNG3 16p13-p12.1 calcium channel, voltage-dependent, gamma subunit 3 RNU7P3 16p12.3 RNA, U7 small nuclear pseudogene 3 RBBP6 16p12-p11.2 retinoblastoma binding protein 6 TNRC6 16p12.1-p11.2 trinucleotide repeat containing 6 KST1 16p12.2-p11.2 trinucleotide repeat containing 6 RICH1 16p12-p11.2 Homo sapiens homolog of rat nadrin (RICH1), mRNA. LOC390685 16 hypothetical gene supported by BC041358
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5078 - 223 - Hirst (2007)
    an additional exon between exons 6 and 7, lacking downstream sequence
    17 - 5973 67.2 613 - Hirst, Wang (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    muscularslow twitch
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • VHS domain at N terminus
  • a typical ear domain at C terminus
  • GAT domain
  • HOMOLOGY
    Homologene
    FAMILY
  • ADP-ribosylation factor binding protein family
  • GGA protein family
  • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • involved in vesicle transport through trans-Golgi (facilitation of the trafficking of proteins between trans-Golgi network and lysosome)
  • sorting MGP receptors and lysosome enzymes
  • implicated in the sorting of mannose 6-phosphate receptor (MPR) (Hida 2007)
  • recruited to the TGN independently of the other GGAs and required for the efficient sorting of lysosomal enzymes (Hida 2007)
  • monomeric clathrin adaptors that mediate cargo sorting and vesicle formation at the TGN (Del Castillo 2010)
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    text heterotopic vesicle/suborganelle interactions associated with the Gogi complex
    PATHWAY
    metabolism
    signaling
    a component
  • complexing through the VHS domain with the cytoplasmic domains of sorting receptors such as the mannose phosphate receptor by recognizing the acidic cluster dileucine (ACLL) sequences
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting by its VHS domain with the cytoplasmic tail of sortilin SORT1
  • binding BACE
  • interaction between GGA1, GGA2, GGA3 and RABEP1 is likely to take place in a pathway between the trans-Golgi network and early endosomes
  • bind PI4P primarily through their GAT domain, in a region called C-GAT that also binds ubiquitin (Wang 2007)
  • associated with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors
  • interacting with CNST (Del Castillo 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS