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FLASH GENE
Symbol GFRA3 contributors: mct/npt - updated : 07-07-2008
HGNC name GDNF family receptor alpha 3
HGNC id 4245
Location 5q31.1-q31.3      Physical location : 137.588.070 - 137.610.253
Synonym name
  • glial cell line-derived neurotrophic factor (GDNF) receptor alpha 3
  • GPI-linked receptor
  • Synonym symbol(s) GFR3, GFR-alpha-3
    DNA
    TYPE functioning gene
    STRUCTURE 22.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    SPOCK 5q31 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) KLHL3 5q31 kelch-like 3 (Drosophila) HNRPA0 5q31 heterogeneous nuclear ribonucleoprotein A0 NPY6R 5q31 neuropeptide Y receptor Y6 (pseudogene) TTID 5q31 titin immunoglobulin domain protein (myotilin) PKD2L2 5q31 polycystic kidney disease 2-like 2 C5orf5 5q31 chromosome 5 open reading frame 5 WNT8A 5q31 wingless-type MMTV integration site family, member 8A NME5 5q31.1 non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) BRD8 5q31.2 bromodomain containing 8 KIF20A 5q31 kinesin family member 20A CDC23 5q31.1 CDC23 (cell division cycle 23, yeast, homolog) GFRA3 5q31.1-q31.3 GDNF family receptor alpha 3 CDC25C 5q31 cell division cycle 25C C5orf6 5q31 chromosome 5 open reading frame 6 C5orf7 5q31 chromosome 5 open reading frame 7 LOC51308 5q31 SGC32445 protein EGR1 5q31.1 early growth response 1 ETF1 5q31.1 eukaryotic translation termination factor 1 HSPA9B 5q31.1 heat shock 70kDa protein 9B (mortalin-2) LOC391836 5 similar to ribosomal protein L10a CTNNA1 5q31.1 catenin (cadherin-associated protein), alpha 1, 102kDa LRRTM2 5q31.3 catenin (cadherin-associated protein), alpha 1, 102kDa SIL1 5q31 endoplasmic reticulum chaperone SIL1, homolog of yeast MATR3 5q31.1-q31.3 matrin 3 PAIP2 5q31.1-q31.3 matrin 3 SLC23A1 20p13 solute carrier family 23 (nucleobase transporters), member 1 PACAP 5q23-5q31 proapoptotic caspase adaptor protein LOC389333 5 LOC389333 LOC389334 5 LOC389334 LOC202051 5q31.3 hypothetical protein LOC202051 MGC29463 5q31.3 hypothetical protein MGC29463
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1980 44.5 400 - Wang (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     stomach    
    Hearing/Equilibriumear   highly
    Nervousbrainhindbraincerebellum predominantly
     gangliaautonomic gangliasympathetic  
     spinal cord    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensory   
    Nervousautonomous   
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     nociceptive cell
    not specificsensory ganglia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to GFRA1,GFRA2,GFRA4
    Homologene
    FAMILY
  • GDNFR family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text anchored to the membrane by a C terminal glycosylphosphatidylinositol (GPI)-linkage
    basic FUNCTION
  • glycosylphosphatidylinositol linked cell surface receptor for artenin (ARTN) activating the RET receptor tyrosine kinase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • artemin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS