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FLASH GENE
Symbol GFRA2 contributors: mct/npt - updated : 07-07-2008
HGNC name GDNF family receptor alpha 2
HGNC id 4244
Location 8p21.3      Physical location : 21.549.529 - 21.646.346
Synonym name
  • glial cell line-derived neurotrophic factor (GDNF) receptor alpha 2
  • neurturin receptor alpha
  • NRTNR-alpha
  • PI-linked cell-surface accessory protein
  • TGF-beta related neurotrophic factor receptor 2
  • RET ligand 2
  • Synonym symbol(s) GDNFRB, RETL2, TRNR2, NTNRA
    DNA
    TYPE functioning gene
    STRUCTURE 58.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC286114 8p21.3 hypothetical protein LOC286114 GFRA2 8p22-p21 GDNF family receptor alpha 2 DOK2 8p21.2 docking protein 2, 56kDa XPO7 8p21 exportin 7 NPM2 8p21.3 nucleophosmin/nucleoplasmin, 2 FGF17 8p21 fibroblast growth factor 17 EPB49 8p21.1 erythrocyte membrane protein band 4.9 (dematin) RAI16 8p21.2 retinoic acid induced 16 FLJ22494 8p21.3 hypothetical protein FLJ22494 HR 8p22-p21 hairless homolog (mouse) FLJ22246 8p21.3 hypothetical protein FLJ22246 LGI3 8p21.2 leucine-rich repeat LGI family, member 3 SFTPC 8p21.2 surfactant, pulmonary-associated protein C BMP1 8p21.2 bone morphogenetic protein 1 PHYHIP 8p21.2 phytanoyl-CoA hydroxylase interacting protein POLR3D 8q21 polymerase (RNA) III (DNA directed) polypeptide D, 44kDa PIWIL2 8p21.2 piwi-like 2 (Drosophila) SLC39A14 8p21.2 solute carrier family 39 (zinc transporter), member 14 PPP3CC 8p21.2 protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) LOC389639 8 LOC389639 SCAM-1 8p21.2 vinexin beta (SH3-containing adaptor molecule-1) PDLIM2 8p21.2 PDZ and LIM domain 2 (mystique) DBC-1 8p22 p30 DBC protein BIN3 8p21.2 bridging integrator 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3376 51.5 464 - Vanhorne, Quartu(2007)
    - - splicing 399 - - - Vanhorne
    missing exons 2 and 3
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrainmidbrainnuclei highly
    Respiratorylung    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, brain, gut, intestine
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four cysteine residues linked by hinge regions
  • secondary structure nine alpha helices with two central beta strands
    conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to GFRA1,GFRA3,GFRA4
    Homologene
    FAMILY
  • GDNFR family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text anchored to the membrane by a C terminal glycosylphosphatidylinositol (GPI)-linkage
    basic FUNCTION
  • glycosylphosphatidylinositol linked cell surface coreceptor for GDNF, involved in RET signaling pathway
  • mediating the autophosphorylation of RET
  • also receptor for neurturin and TGF-beta-related neurotrophic factor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS