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FLASH GENE
Symbol GET4 contributors: mct - updated : 05-01-2016
HGNC name golgi to ER traffic protein 4 homolog (S. cerevisiae)
HGNC id 21690
Location 7p22.3      Physical location : 916.190 - 936.071
Synonym name
  • chromosome 7 open reading frame 20
  • conserved edge protein
  • transmembrane domain recognition complex, 35kDa
  • Synonym symbol(s) CGI-20, C7orf20, H_NH1244M04.5, CEE, TRC35
    DNA
    TYPE functioning gene
    STRUCTURE 19.88 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2106 36.4 327 - 2013 23723067
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine    
     stomach    
    Lymphoid/Immunethymus    
    Reproductivefemale systemovary   
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • UPF0363 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • GET4 and UBL4A are found mainly in cytoplasm
  • UBL4A and GET4 translocate to the nucleus upon DNA damage and appear to play redundant roles in cell killing, as depletion of either one has no effect but co-depletion leads to resistance
  • basic FUNCTION
  • role for GET4/UBL4A in recycling ASNA1 from the ER membrane at the end of the targeting reaction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • three-protein complex composed of BAT3, GET4 and UBL4A
  • heterotrimeric BAG6 complex, which also includes UBL4A and transmembrane domain recognition complex 35 (GET4)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BAG6, GET4 and UBL4A facilitates tail-anchored (TA) protein capture by ASNA1
  • GET4-mediated regulation of ATP hydrolysis by ASNA1 is essential to efficient tail-anchor (TA)-protein targeting
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS