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FLASH GENE
Symbol GEN1 contributors: SGE/npt/shn - updated : 02-01-2011
HGNC name Gen homolog 1, endonuclease (Drosophila)
HGNC id 26881
Location 2p24.2      Physical location : 17.935.176 - 17.966.632
Synonym name
  • flap endonuclease GEN homolog 1
  • Synonym symbol(s) Gen, FLJ40869, DKFZp781F0986
    EC.number 3.1.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 31.46 kb     14 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map pter - D2S332 - D2S2155 - GEN1 - D2S320 - D2S2375 - cen
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 6226 - 908 - -
    14 - 6367 - 908 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Lymphoid/Immunethymus    
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Gen1, Mus musculus
    ortholog to Gen1, Rattus norvegicus
    ortholog to GEN1, Pan troglodyte
    ortholog to Yen1, yeast S.cerevisiae
    Homologene
    FAMILY
  • Rad2/XPG nuclease
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • promoting Holliday junction resolution wich is essential for chromosome segregation at meiosis and the repair of stalled/collapsed replication forks in mitotic cells
  • capable of cleaving replication fork and 5' flap substrates (Svendsen 2010)
  • FEN1, EXO1, ERCC5, and GEN1 are junction specific enzymes that require three separate binding sites for DNA and that incise one base pair into the duplex region of the substrate
  • GEN1 and the BTBD12-associated nucleases MUS81 and SLX1A are essential for the resolution of replication-induced Holliday junctions '
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • a monomeric 5'-flap endonuclease
  • a component
  • EXO1, ERCC5, and GEN1, whose activities span multiple DNA repair pathways, are members of the 5 prime nuclease superfamily with FEN1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binding two Mg2+ ions per subunit
  • protein
    cell & other
  • Holliday junction resolution
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS