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FLASH GENE
Symbol GEMIN5 contributors: mct/npt - updated : 16-06-2008
HGNC name gem (nuclear organelle) associated protein 5
HGNC id 20043
Location 5q33.2      Physical location : 154.266.975 - 154.317.776
Synonym name gemin 5
Synonym symbol(s) MGC142174, DKFZp586M1824
DNA
TYPE functioning gene
STRUCTURE 50.80 kb     28 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
GLULL1 5q33 glutamate-ammonia ligase (glutamine synthase)-like 1 NMU2R 5q33.2 neuromedin U receptor 2 GRIA1 5q33 glutamate receptor, ionotropic, AMPA 1 C5orf3 5q31-q32 chromosome 5 open reading frame 3 MFAP3 5q32 microfibrillar-associated protein 3 GALNT10 5q33.2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) FLJ11526 5q33.2 hypothetical protein FLJ11526 HAND1 5q32 heart and neural crest derivatives expressed 1 LOC389339 5 LOC389339 LARP 5q33.2 likely ortholog of mouse la related protein C5orf4 5q31-q32 chromosome 5 open reading frame 4 CNOT8 5q31-q33 CCR4-NOT transcription complex, subunit 8 GEMIN5 5q33.3 gem (nuclear organelle) associated protein 5 MRPL22 5q33.1-q33.3 mitochondrial ribosomal protein L22 LOC285643 5q33.2 similar to Chromosome-associated kinesin KIF4A (Chromokinesin) LOC391842 5 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) LOC389340 5 LOC389340 SGCD 5q33 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) LOC153743 5q33.3 similar to protein phosphatase 1, regulatory (inhibitor) subunit 2 LOC91937 5q33.3 hypothetical protein BC008988 HAVCR1 5q33.2 hepatitis A virus cellular receptor 1 HAVCR2 5q34 hepatitis A virus cellular receptor 2 CRSP9 5q33.2 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa MGC26988 5q33.3 hypothetical protein MGC26988 ITK 5q33.1 IL2-inducible T-cell kinase CYFIP2 5q34 cytoplasmic FMR1 interacting protein 2 LOC348938 5q33.3 hypothetical protein LOC348938 ADAM19 5q32-q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) SOX30 5q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) LOC389341 5 similar to RIKEN cDNA 4921536K21 FLJ20546 5q33.3 hypothetical protein FLJ20546
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
28 - 5404 - 1508 - Lee (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
Lymphoid/Immunelymph node   highly
Reproductivemale systemtestis  highly
Urinarybladder    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 13 WD domains (WD-40 repeat) in the N terminus
  • a coiled-coil motif near the C terminus
  • mono polymer heteromer , complex
    HOMOLOGY
    Homologene
    FAMILY
  • WD repeat gemin-5 family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,coiled bodies (Cajal)
    text subnuclear structures next to coiled bodies called gems
    basic FUNCTION
  • playing a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (sn RNPs)
  • playing a role in pre m-RNA splicing
  • playing a role in the assembly of transcriptosomes
  • functioning as the factor that allows the SMN complex to distinguish snRNAs from other cellular RNAs for snRNP biogenesis
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the SMN complex
  • component of the spliceosomal complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SNRPB1, SNRPD2, SNRPD3, SNRPE
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    alterations in the expression of a spliceosome protein can effect both specific splicing events and tumor cell motility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS