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FLASH GENE
Symbol GDPD5 contributors: mct/npt - updated : 23-01-2017
HGNC name glycerophosphodiester phosphodiesterase domain containing 5
HGNC id 28804
Location 11q13.4      Physical location : 75.145.685 - 75.236.599
Synonym name glycerophosphodiester phosphodiesterase 2
Synonym symbol(s) PP1665, GDE2
EC.number 3.1.-.-
DNA
TYPE functioning gene
STRUCTURE 90.91 kb     17 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 3193 68.6 605 - 2005 16195461
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex highly Homo sapiensFetal
Reproductivemale systemtestis  highly
 male systemprostate  lowly
Urinarybladder   highly
 kidney   lowly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • GP-PDE-like extracellular motif expressed during osteoblast differentiation and playing an important role in the regulation of cytoskeletal modification
  • six transmembrane regions
  • a GDPD motif
  • HOMOLOGY
    interspecies ortholog to murine Gdpd5
    Homologene
    FAMILY
  • glycerophosphoryl diester phosphodiesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text localized in the cytoplasm (Lang 2008)
    basic FUNCTION
  • serpentine membrane protein acting as a glycerophosphodiester phosphodiesterase
  • being necessary and sufficient to drive spinal motor neuron differentiation
  • physiological role involving neuronal differentiation (Corda 2009)
  • controls the onset and progression of spinal motor neuron differentiation through extracellular glycerophosphodiester phosphodiesterase metabolism.
  • contributing to osmoregulation of glycerophosphocholine in the renal medulla
  • glycerophosphocholine (GPC) phosphodiesterase that contributes to accumulation of GPC in cells exposed to osmotic stress
  • neuronal GDPD5 controls motor neuron subtype diversity through a non-cell-autonomous feedback mechanism that directly regulates progenitor cell differentiation
  • key role for GDPD5 in controlling cortical neuronal fates by regulating the timing of neurogenesis, and loss of GDPD5 uncovers additional mechanisms that trigger remaining neuronal progenitors to differentiate at the end of the neurogenic period
  • induces spinal motor neuron differentiation by inhibiting NOTCH signaling in adjacent motor neuron progenitors
  • its function requires activity of its extracellular domain that shares homology with glycerophosphodiester phosphodiesterases (GDPDs)
  • cleaves glycosylphosphatidylinositol (GPI) anchors
  • six-transmembrane protein that induces differentiation by downregulating NOTCH signalling through surface cleavage of GPI-anchored proteins
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRDX1 interacts with GDPD5, and loss of PRDX1 causes motor neuron deficits analogous to GDPD5 ablation
  • promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK
  • targeted by PRDX4 oxidative activity (PRDX4 dimers oxidize two cysteine residues within the GDPD5 enzymatic domain, which blocks GDPD5 trafficking to the plasma membrane and prevents GDPD5 neurogeneic function)
  • cell & other
    REGULATION
    induced by retinoid
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    silencing GDPD5 and GPCPD1 alone or in combination may have potential as a new molecular targeting strategy for breast cancer treatment
    ANIMAL & CELL MODELS
  • mice lacking Gde2, a six-transmembrane protein that triggers motor neuron generation, exhibit selective losses of distinct motor neuron subtypes, specifically in defined subsets of limb-innervating motor pools that correlate with the loss of force-generating alpha motor neurons