basic FUNCTION
| required for the formation of limb, ear, and skull joints |
|
controlling developmental patterning of skeletal joints and associated with numerous, distant cis-acting |
|
regulatory elements |
|
may be involved in bone formation |
|
plays a role in formation of a diverse subset of skeletal joints |
|
plays an inhibitory role to prevent the osteogenic differentiation of the coronal suture mesenchyme |
|
role for GDF6 in adipocytic commitment and differentiation |
|
may play an important role in suppression of ossification to ensure proper vertebral segmentation during spinal development |
|
GDF6 plays a necessary role in early cochlear development controlled by cis-regulatory elements |
|
GDF6 promotes a healthy disc tissue phenotype in degenerate Nucleus Pulposus (NP)cells through SMAD-dependent and -independent (ERK1/2) mechanisms |