basic FUNCTION
| differentiation of cholinergic central nervous system neurons |
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potent synergistic factor for hematopoietic progenitor-cell generation and colony formation and may play a role in the induction and maintenance of the neuronal cholinergic phenotype in the central nervous system |
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may function as a tumor suppressor and apoptosis regulator in prostate cancer |
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circulating under a biologically active form, is a potent antiangiogenic factor that is likely to play a physiological role in the control of adult blood vessel quiescence |
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potent antiangiogenic factor that is likely to play a physiological role in the control of adult blood vessel quiescence |
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potently induces osteogenesis and chondrogenesis, has been implicated in the differentiation of cholinergic neurons, and may help regulate glucose metabolism |
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inducing Smad1/5 phosphorylation in human pulmonary artery endothelial cells, also stimulating Smad2 activation and inducing the expression of interleukin 8 and E-selectin |
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specifically plays a physiologic role in the control of adult blood-vessel maintenance and angiogenesis by targeting ALK1 on endothelial cells |
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cholinergic differentiating factor during development |
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mutual regulation by GDF2 and BMPER is essential in regulating the development of the vascular endothelium |
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GDF2 and BMP10 are important in postnatal vascular remodeling of the retina and BMP10 can substitute for GDF2 |
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TMEM100 may play indispensable roles downstream of GDF2/BMP10-ACVRL1 signaling during endothelial differentiation and vascular morphogenesis |
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implicated in regulation of the CXCL12/CXCR4 chemokine axis in endothelial cells (PMID; |
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GDF2 signaling may be relevant during hepatocarcinogenesis |
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exogenous CRELD2 promotes GDF2-induced ectopic bone formation and matrix mineralization, whereas silencing CRELD2 expression diminishes GDF2-induced bone formation and matrix mineralization |