basic FUNCTION
| regulates tissue differenciation and maintenance |
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reduces the growth of granulocytes and macrophages, as an autocrine/paracrine regulatory molecule |
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may promote fetal survival by suppressing the production of maternally derived proinflammatory cytokines within the uterus |
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activates signal transduction |
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regulator of hepcidin, not the sole regulator of its expression, but instead contributes to the suppression of hepcidin in the pathological setting of thalassemia |
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antihypertrophic factor which is induced in the heart in response to pressure overload and plays an important |
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seems to be an important determinant of renal collecting duct lengthening ( |
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regulatory role in the process of hypertrophy (Wang 2009) |
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involved in the control of multiple cellular processes and mediates cachexia through the inhibition of appetite (Ding 2009) |
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may have a paracrine role in the modulation of adipose tissue function and body fat mass (Ding 2009) |
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production of GDF15 by erythroid cells is dependent on both EPO and TFR2 |
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is among the erythroid factors down-regulating hepcidin and contributing to iron overload in conditions of dyserythropoiesis |
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could play a pivotal role in the pathogenesis of bone loss relevant to hypoxia through promotion of osteoclastogenesis after secretion from adjacent osteocytes during disuse and/or ischemia in bone |
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specifically inhibits platelet integrin activation |
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play a role in cell proliferation, apoptosis, cell metastasis, and angiogenesis through autocrine and paracrine signaling |
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may be one of the critical molecules that inhibit dendritic cells maturation and function and are involved in tumor immune escape |
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regulates likely migration and proliferation by promoting EGFR signalling in the postnatal hippocampus (HP) |
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nuclear GDF15 contributes to inhibition of the Smad pathway by interrupting the Smad complex, and controls transcriptional regulation in the Smad pathway |
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secreted cytokine, a direct target of TP53, playing a role in cell proliferation and apoptosis |