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FLASH GENE
Symbol GDE1 contributors: mct/npt - updated : 15-01-2010
HGNC name glycerophosphodiester phosphodiesterase 1
HGNC id 29644
Location 16p12.3      Physical location : 19.513.016 - 19.533.450
Synonym name membrane interacting protein of RGS16
Synonym symbol(s) 363E6.2, MIR16
EC.number 3.1.4.44
DNA
TYPE functioning gene
STRUCTURE 20.43 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2960 37 331 - Bachmann (2006)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 liver    
Nervousbrain    
Reproductivefemale systemovary   
 male systemprostate   
Respiratorylung    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative catalytic domain that shares a common motif (amino acids 92-116), with an amino acid sequence resembling the known HKD signature of the phospholipase D family (Corda 2009)
  • the catalytic domains of mammalian phosphoinositide phospholipases C
  • two hydrophobic domains
  • a GDE domain that shares strong homologies with GDE1-related proteins as well as bacterial GDPDs
  • HOMOLOGY
    interspecies homolog to rat Mir16
    Homologene
    FAMILY
  • glycerophosphoryl diester phosphodiesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • providing a link between phosphoinositide metabolism and G protein signal transduction
  • catalyzes the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol (Bachmann 2006)
  • mediate glycerophosphoinositol catabolism, leading to different products, potentially reflecting the specific function(s) of glycerophosphoinositol in a given cell system/tissue (Corda 2009)
  • may be involved in the biosynthesis of anandamide (N-arachidonoyl ethanolamine), an endogenous ligand for the brain cannabinoid receptor (Corda 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with regulator of G protein signaling proteins
  • interacting protein of the regulator of G protein signaling 16 (RGS16) providing a link between phosphoinositide metabolism and G protein signal transduction (Bachmann 2006)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS