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FLASH GENE
Symbol GDA contributors: - updated : 04-09-2007
HGNC name guanine deaminase
HGNC id 4212
Location 9q21.11-21.33      Physical location : 74.764.292 - 74.867.139
Synonym name
  • rat guanine aminohydrolase homolog
  • cytoplasmic PSD95 interactor
  • Synonym symbol(s) KIAA1258, CYPIN, NEDASIN, GUANASE
    EC.number 3.5.4.3
    DNA
    TYPE functioning gene
    STRUCTURE 102.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Physical map
    PRKACG 9q13 protein kinase, cAMP-dependent, catalytic, gamma FRDA 9q13-q21.1 Friedreich ataxia LOC392347 9 similar to adenylate kinase 3 alpha like TJP2 9q13-q21 tight junction protein 2 (zona occludens 2) C9orf61 9q13-q21 chromosome 9 open reading frame 61 APBA1 9q13-q21 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) LOC375743 9q21.13 similar to CG3073-PA LOC138255 9q21.13 similar to RIKEN cDNA 1700028P14 MAMDC2 9q21.2 MAM domain containing 2 RNU2P3 9q21.2 RNA, U2 small nuclear pseudogene 3 SMC5L1 9q21.11 SMC5 structural maintenance of chromosomes 5-like 1 (yeast) BTEB1 9q13 basic transcription element binding protein 1 TRPM3 9q21.13 transient receptor potential cation channel, subfamily M, member 3 LOC392348 9 similar to CDC91 cell division cycle 91-like 1; GPI transamidase component C9orf63 9q21.2 chromosome 9 open reading frame 63 TMEM2 9q13-q21 transmembrane protein 2 CGI-67 MGC61599 LOC392349 9 similar to Heat shock 27 kDa protein (HSP 27) (Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein) C9orf57 9q21.2 chromosome 9 open reading frame 57 LOC392350 9 similar to Transcription factor BTF3 (RNA polymerase B transcription factor 3) GDA 9q21.11-21.33 guanine deaminase ZNF216 9q21.11 zinc finger protein 216 TMC1 9q13-q21 transmembrane, cochlear expressed, 1 ALDH1A1 9q21.1 aldehyde dehydrogenase 1 family, member A1 ANXA1 9q13-q21.2 annexin A1 LOC392351 9 similar to tMDC I LOC138971 9q21.31 similar to dipeptidylpeptidase III isoform 1; dipeptidylpeptidase III LOC138972 9q21.31 similar to Centaurin gamma 2 RORB 9q22 RAR-related orphan receptor B TRPM6 9q21.13 transient receptor potential cation channel, subfamily M, member 6 C9orf40 9q21.31 chromosome 9 open reading frame 40 C9orf41 9q21.31 chromosome 9 open reading frame 41 FLJ20559 9q21.31 hypothetical protein FLJ20559 OSTF1 12q24.1-q24.2 osteoclast stimulating factor 1
    RNA
    TRANSCRIPTS type messenger
    text four alternative splice variants (S,V1,V2,V3) (Kuwahara)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousbrain   highly
    Reproductivefemale systemuterus  highly
    Respiratorylung    
    Urinarykidneytubuleconvoluted tubuleproximal tubule 
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text in developing dendrites
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • a nine residue N terminal motif that is present in other aminohydrolases and amidohydrolases
  • zinc binding, collapsin response mediator protein (CRMP) homology domain
  • PSD-95, Discs large, zona occludens-1 binding domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila CG18143
    homolog to C.elegans T20D4.9
    homolog to rattus guanine aminohydrolase
    homolog to murine Gda guanine deaminase
    intraspecies homolog to CRMP1,weakly
    Homologene
    FAMILY ATZ/TRZ family
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the hydrolytic deamination of guanine
  • producing xanthine and ammonia
  • may have a role in clustering neurotransmitter receptors
  • may influence synaptic development and plasticity by regulating postsynaptic protein sorting
  • regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly
  • decreases PSD-95 family member localization and regulates dendrite number
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis, synaptic development and plasticity
    PATHWAY
    metabolism nucleic , purine/pyrimidine
    signaling
    purine nucleotide catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+ (one ion per subunit)
    protein
  • regulating DLG4 (PSD-95) postsynaptin targeting
  • binds directly to tubulin heterodimers and promotes microtubule polymerization, via its CRMP homology domain to promote microtubule assembly
  • interacting with SNAPAP (coiled-coil domain (H2) of SNAPAP is required for GDA binding)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS