Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GDA contributors: - updated : 04-09-2007
HGNC name guanine deaminase
HGNC id 4212
Location 9q21.11-21.33      Physical location : 74.764.292 - 74.867.139
Synonym name
  • rat guanine aminohydrolase homolog
  • cytoplasmic PSD95 interactor
  • Synonym symbol(s) KIAA1258, CYPIN, NEDASIN, GUANASE
    EC.number 3.5.4.3
    DNA
    TYPE functioning gene
    STRUCTURE 102.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text four alternative splice variants (S,V1,V2,V3) (Kuwahara)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousbrain   highly
    Reproductivefemale systemuterus  highly
    Respiratorylung    
    Urinarykidneytubuleconvoluted tubuleproximal tubule 
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text in developing dendrites
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • a nine residue N terminal motif that is present in other aminohydrolases and amidohydrolases
  • zinc binding, collapsin response mediator protein (CRMP) homology domain
  • PSD-95, Discs large, zona occludens-1 binding domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila CG18143
    homolog to C.elegans T20D4.9
    homolog to rattus guanine aminohydrolase
    homolog to murine Gda guanine deaminase
    intraspecies homolog to CRMP1,weakly
    Homologene
    FAMILY ATZ/TRZ family
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the hydrolytic deamination of guanine
  • producing xanthine and ammonia
  • may have a role in clustering neurotransmitter receptors
  • may influence synaptic development and plasticity by regulating postsynaptic protein sorting
  • regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly
  • decreases PSD-95 family member localization and regulates dendrite number
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis, synaptic development and plasticity
    PATHWAY
    metabolism nucleic , purine/pyrimidine
    signaling
    purine nucleotide catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+ (one ion per subunit)
    protein
  • regulating DLG4 (PSD-95) postsynaptin targeting
  • binds directly to tubulin heterodimers and promotes microtubule polymerization, via its CRMP homology domain to promote microtubule assembly
  • interacting with SNAPAP (coiled-coil domain (H2) of SNAPAP is required for GDA binding)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS