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FLASH GENE
Symbol GCNT1 contributors: - updated : 07-02-2007
HGNC name glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
HGNC id 4203
Location 9q13-q21      Physical location : 79.056.581 - 79.122.330
Synonym name
  • beta-1,6-N-acetylglucosaminyltransferase 1
  • beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
  • core 2 beta-1,6-N-acetylglucosaminyltransferase I
  • Synonym symbol(s) IGNT,GGNT, NACGT2, RP11-214N16.1, C2GNT, C2GNT-L, C2GNT1, G6NT, MGC126335, MGC126336, NACGT2, NAGCT2
    EC.number 2.4.1.102
    DNA
    TYPE like-sequence
    STRUCTURE 49.00 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     stomach   highly
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage myeloids cells, highly
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Gcnt1
    Homologene
    FAMILY glycosyltransferase 14 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • beta-1,6-N-acetyl-glucosaminyl transferase 1,leukocyte type core 2 branching enzyme in O-glycans
  • forms critical branches in O-glycans
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to prostate carcinoma (in Japanese population)
    Variant & Polymorphism other GG genotype had a 3.60-fold increased risk of prostate cancer, and the AG genotype had a 1.58-fold increased risk of prostate cancer compared with those with the AA genotype
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS