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FLASH GENE
Symbol GCN1L1 contributors: KTN/npt - updated : 08/10/2008
HGNC name GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
HGNC id 4199
Location 12q24.2      Physical location : 120.565.015 - 120.632.513
Synonym name GCN1 (general control of amino-acid synthesis, yeast, homolog)-like
Synonym symbol(s) GCN1, GCN1L, KIAA0219
DNA
TYPE functioning gene
STRUCTURE 67.50 kb     58 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D12S366 - GCN1L1 - NME2 - D12S86 - D12S349 - D12S321 - BDKRB2 - D12S342 - D12S340 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
58 - 8699 292.6 2671 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   moderately
 pancreas exocrine   moderately
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuteruscervix highly
 female systemovary  moderately
 female systembreastmammary gland highly
 male systemprostate  moderately
Respiratoryrespiratory tractlarynx  highly
Skin/Tegumentskin   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  moderately
cell lineage
cell lines
fluid/secretion moderately in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twenty four HEAT repeats
  • an EF3 (eukariotic translation elongation factor)-like domain
  • conjugated Other
    HOMOLOGY
    interspecies homolog to dog GCN1L1 (96.8 pc)
    homolog to chimpanzee GCN1L1 (99.7 pc)
    homolog to cow GCN1L1 (96.1 pc)
    homolog to rattus Gcn1l1 (94.3 pc)
    homolog to murine Gcn1l1 (94 pc)
    Homologene
    FAMILY
  • GCN1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • acting as a translational regulator of the activator GCN4
  • potentially functioning on elongating ribosomes in activation of EIF2 alpha kinase GCN2
  • preventing the interaction with GCN2 protein kinase (EIF2AK1-4)
  • CELLULAR PROCESS protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IMPACT
  • cell & other
    REGULATION
    Other acetylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS