basic FUNCTION
| a critical role in trophoblast differentiation and the signal transduction processes required for normal vascularization of the placenta ( |
|
placenta-specific transcriptional regulator possibly involved in the expression of multiple placenta-specific genes |
|
playing a functional role contributing to constitutively high trophoblast PGF expression and is the first direct evidence of an oxygen-responsive, trophoblast-specific transcription factor contributing to the regulation of PGF expression (Chang 2006) |
|
involved with exchange between maternal and fetal blood supplies |
|
neural transcription factor |
|
regulates expression of syncytin, a placental fusogenic protein mediating trophoblastic fusion (Chuang 2006) |
|
involved in the epigenetic regulation of Hes5 transcription by DNA demethylation independently of DNA replication ( |
|
novel function of GCM1 and HTRA4 in regulation of trophoblast invasion and abnormal HTRA4 expression may contribute to shallow trophoblast invasion in preeclampsia |
|
regulates placental cell fusion into the syncytiotrophoblas |
|
GCM1 and FZD5 function in an evolutionary conserved positive feedback loop that regulates trophoblast differentiation and sites of chorionic branching morphogenesis |
|
regulates trophoblast differentiation and function during placentation ( |