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FLASH GENE
Symbol GCLM contributors: - updated : 26-04-2006
HGNC name glutamate-cysteine ligase, modifier subunit
HGNC id 4312
Location 1p22.1      Physical location : 94.352.589 - 94.375.012
Synonym name glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)
Synonym symbol(s) GLCLR
EC.number 6.3.2.2
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure an antioxidant response element (ARE) and a 44-bp fragment upstream of the ARE,including a consensus AP-1 site previously considered responsible for the enhancer activity of the upstream fragment.
MAPPING cloned Y linked N status confirmed
Physical map
ABHD7 1p22.1 abhydrolase domain containing 7 LOC339526 1p22.1 similar to hypothetical protein FLJ20481 LOC126598 1p22.1 similar to template acyivating factor-I alpha LOC284697 1p22.1 similar to agCP5986 KIAA1107 1p22.1 KIAA1107 protein LOC388649 1 similar to 1700028K03 protein GLMN 1p22.1 glomulin, FKBP associated protein FLJ13150 1p22.1 hypothetical protein FLJ13150 GFI1 1p22 growth factor independent 1 EVI5 1p22 ecotropic viral integration site 5 RPL5 1p22.1-p21.3 ribosomal protein L5 LOC388650 1 similar to RIKEN cDNA 2900024C23 M96 1p22.1 likely ortholog of mouse metal response element binding transcription factor 2 CGI-100 1pter-q31.3 CGI-100 protein NY-SAR-41 1p22.1 sarcoma antigen NY-SAR-41 DR1 1p22.1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) FLJ20275 BCAR3 1p22.1 breast cancer anti-estrogen resistance 3 LOC388651 1 LOC388651 HSU15552 1p22.1 acidic 82 kDa protein mRNA GCLM 1p22.1 glutamate-cysteine ligase, modifier subunit ABCA4 1p22.1 ATP-binding cassette, sub-family A (ABC1), member 4 PARG1 1p22.1 PTPL1-associated RhoGAP 1 LOC391057 1 similar to uracil DNA glycosylase ABCD3 1p22.1-p21.3 ATP-binding cassette, sub-family D (ALD), member 3 F3 1p22.1-p21 coagulation factor III (thromboplastin, tissue factor) MGC45474 1p22.1 hypothetical protein MGC45474 CNN3 1p21 calponin 3, acidic MGC19780 1p22.1 hypothetical protein MGC19780 FLJ31842 1p22.1 hypothetical protein FLJ31842 RWDD3 1p22.1 RWD domain containing 3 LOC388652 1 LOC388652
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
 parathyroid   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
Homologene
FAMILY
  • aldo/keto reductase family
  • glutamate-- cysteine ligase light chain subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • regulatory subunit, catalyzing the first step of GSH synthesis, gamma-glutamyl cycle
  • implicated in some forms of hemolytic anemia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    located in the critically deleted region of malignant mesothelioma (see TSG1)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS